U.S. stock index futures edged higher on Wednesday ahead of the Federal Reserve's monetary policy decision, while the Israel-Iran conflict entered its sixth day, with new missile strikes launched from both sides.

A Federal Reserve monetary policy decision is due at 02:00 p.m. ET where policymakers are widely expected to leave interest rates unchanged at the 4.25%-4.5% range.

Market Snapshot

At 7:50 a.m. ET, Dow E-minis were up 63 points, or 0.15%, S&P 500 E-minis were up 13.25 points, or 0.22%. Nasdaq 100 E-minis were up 65.5 points, or 0.3%.

Pre-Market Movers

Circle - Circle shares gained 3% in premarket trading. The U.S. Senate on Tuesday passed a bill to create a regulatory framework for U.S.-dollar-pegged cryptocurrency tokens known as stablecoins, in a watershed moment for the digital asset industry.

Regencell Bioscience - Regencell Bioscience shares pulled back 12% in premarket trading. The company’s year to date performance is off the charts too, having risen 59,900% in 2025. Its current market value of $36 billion tops Lululemon, eBay and Kraft Heinz. The shares traded for pennies at one point in the past one year.

AMD - AMD shares gained 2% in premarket trading. Microsoft announced a multiyear partnership with AMD on Tuesday to develop custom silicon for its next-generation Xbox consoles, marking the latest step in.

Oil Stocks - Some oil stocks jumped again as Iran-Israel conflict entered sixth day. Robin Energy rose 12%; Indonesia Energy rose 6%; Battalion Oil rose 5%; US Energy rose 4%; TMD Energy rose 3%.

Li Auto - US-listed shares of Li Auto fell another 1.4% after sinking 4.5% yesterday. Wang Xing, Non-Executive Director of Li Auto and Chairman of Meituan, reduced his stake in Li Auto by selling a total of 5.7357 million H shares over four consecutive days from June 10 to 13, according to the disclosure of interests from the Hong Kong Stock Exchange.

Scholar Rock - Scholar Rock said on Wednesday its experimental drug helped overweight patients preserve lean mass in a mid-stage trial when used in combination with Eli Lilly's weight-loss treatment Zepbound. Shares of Scholar Rock jumped 14% in premarket trading.

Bitdeer Technologies - Singapore-based Bitdeer Technologies fell 6.3% after the Bitcoin mining technology company said it plans to offer $300 million of convertible senior notes.

Aurora Cannabis - Aurora Cannabis shares dropped 22% in premarket trading. Aurora Cannabis's loss narrowed in its fiscal fourth quarter thanks to strong growth in its medical-cannabis business.

Market News

Israel-Iran Air War Enters Sixth Day, Trump Calls for Iran's "Unconditional Surrender"

Iran and Israel launched new missile strikes at each other on Wednesday as the air war between the two longtime enemies entered a sixth day despite a call from U.S. President Donald Trump for Tehran's unconditional surrender.

The Israeli military said two barrages of Iranian missiles were launched toward Israel in the first two hours of Wednesday morning. Explosions were heard over Tel Aviv.

Israel told residents in a southwestern area of Tehran to evacuate so its air force could strike Iranian military installations. Iranian news websites said Israel was attacking a university linked to Iran's Revolutionary Guards in the east of the capital.

US Senate Passes Stablecoin Bill in Milestone for Crypto Industry

The U.S. Senate on Tuesday passed a bill to create a regulatory framework for U.S.-dollar-pegged cryptocurrency tokens known as stablecoins, in a watershed moment for the digital asset industry.

The bill, dubbed the GENIUS Act, received bipartisan support, with several Democrats joining most Republicans to back the proposed federal rules. It passed 68-30. The House of Representatives, which is controlled by Republicans, needs to pass its version of the bill before it heads to President Donald Trump's desk for approval.

Stablecoins, a type of cryptocurrency designed to maintain a constant value, usually a 1:1 dollar peg, are commonly used by crypto traders to move funds between tokens. Their use has grown rapidly in recent years, and proponents say that they could be used to send payments instantly.

Trump Again Pushes TikTok Sale Deadline With 90-Day Extension

President Donald Trump is extending for a third time the deadline for Chinese company ByteDance Ltd. to divest the American operations of TikTok, allowing the social media app to keep running in the US while negotiations proceed.

“As he has said many times, President Trump does not want TikTok to go dark,” White House Press Secretary Karoline Leavitt said in a statement Tuesday. “This extension will last 90 days, which the Administration will spend working to ensure this deal is closed so that the American people can continue to use TikTok with the assurance that their data is safe and secure.”

The decision provides yet another lifeline for the popular app that spurred worries in Washington over national security and which has emerged as a source of friction between the US and China. For Trump, who regards himself as the consummate dealmaker, the reprieve gives him more time to secure a complicated agreement that would require an American buyer and Beijing’s sign-off.