HeartFlow Inc (HTFL) experienced a significant pre-market plunge of 11.62% on Thursday, as the stock continued its downward momentum following the release of quarterly financial results.

The decline comes after the company reported its fourth quarter and full year 2025 earnings, which showed an adjusted loss of $0.12 per share that beat analyst expectations of a $0.17 loss. Revenue also exceeded estimates at $49.1 million, representing a 40% year-over-year increase. However, investors focused on the company's ongoing profitability challenges, including a net loss of $24.4 million for the quarter.

Market participants appear to be reacting to concerns about HeartFlow's continued losses despite revenue growth, as well as the company's 2026 revenue guidance of $218-222 million, which while above analyst expectations, may not have met some investors' more optimistic projections for the AI-driven cardiovascular care technology company. Additionally, JP Morgan cut its target price on HeartFlow to $35 from $40, adding to negative sentiment.