TRANSTHERA-B (02617): Phase II Clinical Trial of Tinengotinib Combined with AKESO's Kantani® (Cadonilimab, PD-1/CTLA-4) / Ivonesca® (Ivonescimab, PD-1/VEGF) Completes First Patient Dosing

Stock News

2025/09/04

TRANSTHERA-B (02617) announced that the open-label, multi-center Phase II clinical studies of its core product Tinengotinib (TT-00420) in combination with AKESO Limited's Kantani® (Cadonilimab, PD-1/CTLA-4) / Ivonesca® (Ivonescimab, PD-1/VEGF) for the treatment of advanced hepatocellular carcinoma (HCC) have recently completed first patient dosing.

This trial is an open-label, multi-center Phase II clinical study conducted in China to evaluate the efficacy and safety of Kantani® (Cadonilimab, PD-1/CTLA-4) / Ivonesca® (Ivonescimab, PD-1/VEGF) combined with Tinengotinib tablets for treating advanced hepatocellular carcinoma. The primary objective of the trial is to assess the safety and efficacy of Kantani® (Cadonilimab, PD-1/CTLA-4) / Ivonesca® (Ivonescimab, PD-1/VEGF) respectively combined with Tinengotinib tablets or Tinengotinib monotherapy for advanced hepatocellular carcinoma treatment.

The trial's target population includes patients with advanced hepatocellular carcinoma who have not previously received systemic anti-tumor treatment for hepatocellular carcinoma or those who have failed standard treatment. TRANSTHERA has entered into a cooperation agreement with AKESO, with both parties jointly conducting clinical combination drug development in the field of hepatocellular carcinoma.

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