IMMUNEONCO-B Initiates Phase III Study: First Patient Dosed with Dual-Targeting Therapy IMM0306 for Relapsed/Refractory Follicular Lymphoma

Bulletin Express

03/30

ImmuneOnco Biopharmaceuticals (Shanghai) Inc. (IMMUNEONCO-B) announced that the first patient has been dosed in its Phase III clinical trial evaluating IMM0306 in combination with lenalidomide for the treatment of relapsed/refractory follicular lymphoma (R/R FL).

IMM0306 Profile • Mechanism: A bispecific molecule simultaneously targeting CD47 and CD20. • Clinical Milestone: First CD47/CD20 dual-targeting bispecific therapy to reach the clinical stage globally. • Mode of Action: – Blocks the CD47-SIRPα “don’t eat me” signal, enhancing macrophage-mediated phagocytosis. – Strengthens Fc-FcɣRIIa and Fc-FcɣRIIIa interactions to activate macrophages and natural killer cells. – Prefers CD20 over CD47 binding, aiming to eliminate malignant B cells while minimizing toxicity. • Rights: The Group holds global intellectual property and commercial rights to IMM0306.

Regulatory Note In accordance with Rule 18A.05 of the Hong Kong Listing Rules, IMMUNEONCO-B cautions that successful development and commercialization of IMM0306 are not guaranteed.

The announcement was authorized by Chairman and Executive Director Dr. Tian Wenzhi on 30 March 2026 in Shanghai.

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