Foghorn Therapeutics Ends Solo Development of FHD-286

Dow Jones

2024/12/16

By Colin Kellaher

Foghorn Therapeutics on Monday said it is ending independent development of its FHD-286 drug candidate following disappointing results from an early-stage study.

Foghorn said the objective clinical response rate observed in the Phase 1 dose-escalation study of FHD-286 in combination with decitabine in acute myeloid leukemia didn't meet the threshold for the Cambridge, Mass., clinical-stage biotechnology company to continue development of the drug on its own.

Foghorn said it is evaluating partnerships and investigator-sponsored trials to advance FHD-286, adding that it will now prioritize its other pipeline candidates and its collaboration programs with Eli Lilly.

The company said its $267.4 million in cash, equivalents and marketable securities as of Sept. 30 provide a runway into 2027.

Trading in shares of Foghorn, which closed Friday at $5.30, was halted premarket on Monday.

Write to Colin Kellaher at colin.kellaher@wsj.com

(END) Dow Jones Newswires

December 16, 2024 07:35 ET (12:35 GMT)

Copyright (c) 2024 Dow Jones & Company, Inc.

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Company, Inc.\n</p>\n</font>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4139","symbol_name":"生物科技","start_time":0,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","article_id":"2491754660","we_media_id":"106","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2491754660","pubTimestamp":1734352500,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Dow Jones","introduction":"Dow Jones publishes the world’s most trusted business news and financial information in a variety of media.","home_visible":0,"id":"106","head_image":"https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99"},"summary":"Foghorn Therapeutics on Monday said it is ending independent development of its FHD-286 drug candidate following disappointing results from an early-stage study.Foghorn said the objective clinical response rate observed in the Phase 1 dose-escalation study of FHD-286 in combination with decitabine in acute myeloid leukemia didn't meet the threshold for the Cambridge, Mass., clinical-stage biotechnology company to continue development of the drug on its own.Foghorn said it is evaluating partnerships and investigator-sponsored trials to advance FHD-286, adding that it will now prioritize its other pipeline candidates and its collaboration programs with Eli Lilly.The company said its $267.4 million in cash, equivalents and marketable securities as of Sept. 30 provide a runway into 2027.Trading in shares of Foghorn, which closed Friday at $5.30, was halted premarket on Monday.","collect":0,"end_time":0,"defaultTopTitle":"","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK4139":"生物科技","LENZ":"Therapeutics","FHTX":"Foghorn Therapeutics Inc."},"translate_title":"Foghorn Therapeutics结束FHD-286的单独开发","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"FHTX":1,"LENZ":1},"content_text":"By Colin Kellaher \n\n\n \n\n\n  Foghorn Therapeutics on Monday said it is ending independent development of its FHD-286 drug candidate following disappointing results from an early-stage study. \n\n\n  Foghorn said the objective clinical response rate observed in the Phase 1 dose-escalation study of FHD-286 in combination with decitabine in acute myeloid leukemia didn't meet the threshold for the Cambridge, Mass., clinical-stage biotechnology company to continue development of the drug on its own. \n\n\n  Foghorn said it is evaluating partnerships and investigator-sponsored trials to advance FHD-286, adding that it will now prioritize its other pipeline candidates and its collaboration programs with Eli Lilly. \n\n\n  The company said its $267.4 million in cash, equivalents and marketable securities as of Sept. 30 provide a runway into 2027. \n\n\n  Trading in shares of Foghorn, which closed Friday at $5.30, was halted premarket on Monday. \n\n\n \n\n\n  Write to Colin Kellaher at colin.kellaher@wsj.com \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 16, 2024 07:35 ET (12:35 GMT)\n\n\n  Copyright (c) 2024 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-1","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":true,"code":"91000000","status":"200"}}}