European equities traded in the US as American depositary receipts were lower late Wednesday morning, declining 0.36% to 1,442.32 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by semiconductor company Sequans Communications (SQNS) and internet browser company Opera (OPRA), which rose 3.6% each. They were followed by 3D printer company Materialise (MTLS) and petroleum refiner Equinor (EQNR), which were up 2.2% and 1.9% respectively.

The decliners from continental Europe were led by biopharmaceutical company DBV Technologies (DBVT) and financial services company Banco Bilbao Vizcaya Argentaria (BBVA), which fell 2.5% and 2.1% respectively. They were followed by pharmaceutical companies Ascendis Pharma (ASND) and Novo Nordisk (NVO), which were down 1.8% and 1.3% respectively.

From the UK and Ireland, the gainers were led by biopharmaceutical companies Biodexa Pharmaceuticals (BDRX) and Akari Therapeutics (AKTX), which advanced 25% and 5% respectively. They were followed by biopharmaceutical company Amarin (AMRN) and cruise line operator Carnival (CUK), which increased 4.9% and 3.1% respectively.

The decliners from the UK and Ireland were led by biopharmaceutical company NuCana (NCNA) and biotech firm Trinity Biotech (TRIB), which dropped 3.5% and 2.8% respectively. They were followed by pharmaceutical company GSK (GSK) and medical device maker Smith & Nephew (SNN), which lost 1.9% and 1.7% respectively.