Cassava Sciences' Phase 3 Study of Simufilam Showed No Benefit for Alzheimer's Patients

MT Newswires Live

2025/03/25

Cassava Sciences (SAVA) said Tuesday that topline results from its phase 3 REFOCUS-ALZ study of simufilam showed no treatment benefit for patients with mild-to-moderate Alzheimer's disease.

The biotech company said the results did not meet the co-primary, secondary, and exploratory biomarker endpoints.

The co-primary endpoints were the change in cognition and function from baseline to the end of the double-blind treatment period at week 76 compared to placebo.

Shares of Cassava Sciences were down 18% in recent premarket activity.

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