BUZZ-Cassava falls after stopping development of Alzheimer's drug

Reuters

2025/03/25

** Shares of drug developer Cassava Sciences SAVA.O fall 21.4% to $2.20 premarket

** SAVA says it will discontinue the development of its experimental treatment, simufilam, for Alzheimer's disease, by the end of Q2

** In trials, the drug failed to significantly reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease, compared to placebo

** In November, co said it would stop all trials of the drug

** The drug has been at the center of scrutiny after a medical professor linked to its development was charged with fraud in June

** Stock fell 89.4% since Nov 2024

(Reporting by Siddhi Mahatole)

((siddhi.mahatole@thomsonreuters.com))

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21:17</p>\n</div>\n\n</a>\n\n\n</h4>\n\n</header>\n<article>\n<html xmlns=\"http://www.w3.org/1999/xhtml\"><head><title>BUZZ-Cassava falls after stopping development of Alzheimer's drug</title></head><body><p>** Shares of drug developer Cassava Sciences <span>SAVA.O</span> fall 21.4% to $2.20 premarket</p><p>** SAVA <span>says</span> it will discontinue the development of its experimental treatment, simufilam, for Alzheimer's disease, <span>by the end of Q2</span></p><p>** In <span>trials</span>, the drug failed to <span>significantly </span>reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease, compared to placebo</p><p>** In November, co said it would stop all trials of the drug</p><p>** The drug has been at the center of scrutiny after a medical professor <span>linked</span> to its development was charged with fraud in June</p><p>** Stock fell 89.4% since Nov 2024</p><p> (Reporting by Siddhi Mahatole)</p><p> 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