Apellis Pharmaceuticals (APLS) reported a Q1 loss Wednesday of $0.74 per diluted share, widening from a loss of $0.54 a year earlier.
Analysts polled by FactSet expected a loss of $0.36.
Revenue for the quarter ended March 31 was $166.8 million, down from $172.3 million a year earlier.
Analysts surveyed by FactSet expected $194.0 million.
Shares of the biotech company were down more than 5% in recent premarket activity.