Ascletis Pharma Initiates U.S. Clinical Study Combining ASC47 and Semaglutide for Obesity Treatment

Reuters

05/20

Ascletis Pharma Initiates U.S. Clinical Study Combining ASC47 and Semaglutide for Obesity Treatment

HONG KONG, May 20, 2025/PRNewswire/ -- Ascletis Pharma Inc. (HKEX:1672) has announced the commencement of a new clinical study, the ASC47-103 study, in the United States. The study is a randomized, double-blind, placebo-controlled trial designed to evaluate the safety and preliminary efficacy of a single-dose, ultra-long-acting subcutaneous administration of ASC47 in combination with semaglutide for the treatment of obesity in participants without Type 2 diabetes. The ASC47-103 study involves three cohorts receiving single ascending doses of ASC47 (10 mg, 30 mg, and 60 mg) or a volume-matched placebo, alongside four weekly doses of semaglutide (0.5 mg). This marks the first clinical study combining a THRβ agonist and an incretin drug for obesity. Topline results from the study are anticipated in the fourth quarter of 2025.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ascletis Pharma Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN92026) on May 20, 2025, and is solely responsible for the information contained therein.

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The study is a randomized, double-blind, placebo-controlled trial designed to evaluate the safety and preliminary efficacy of a single-dose, ultra-long-acting subcutaneous administration of ASC47 in combination with semaglutide for the treatment of obesity in participants without Type 2 diabetes. The ASC47-103 study involves three cohorts receiving single ascending doses of ASC47 (10 mg, 30 mg, and 60 mg) or a volume-matched placebo, alongside four weekly doses of semaglutide (0.5 mg). This marks the first clinical study combining a THRβ agonist and an incretin drug for obesity. Topline results from the study are anticipated in the fourth quarter of 2025.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ascletis Pharma Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN92026) on May 20, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK1515","symbol_name":"抗疫概念","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250520:nNDL1LtT0d:1","article_id":"2536613395","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2536613395","pubTimestamp":1747735273,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"HONG KONG, May 20, 2025/PRNewswire/ -- Ascletis Pharma Inc.  has announced the commencement of a new clinical study, the ASC47-103 study, in the United States. 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