US benchmark equity indexes ended lower Tuesday as Wall Street parsed comments by a Federal Reserve official.

* St. Louis Fed President Alberto Musalem said Tuesday that tariffs are expected to "dampen" economic activity and result in "some further softening" of the labor market.

"Tariffs are also likely to have direct one-off effects on the prices of imported final goods, indirect effects on the prices of domestically produced goods and services, and possibly second-round effects on inflation," Musalem said in prepared remarks for an event in Minneapolis. "I believe that monetary policy is well-positioned to navigate material changes in the economic outlook as they become apparent, and to deliver stable prices and maximum employment."

* June West Texas Intermediate crude oil closed down $0.13 to settle at $62.56 per barrel, while July Brent crude, the global benchmark, was last seen down $0.10 to $65.44 amid a weakening global economy and rising supply, though stalled talks between Iran and the United States are easing fears of yet more new barrels coming to market.

* The US Food and Drug Administration plans to require new clinical trials prior to approval of Covid-19 boosters for healthy Americans under the age of 65, agency leaders said Tuesday in a post published in the New England Journal of Medicine. Shares of Moderna (MRNA) and Pfizer (PFE) were up 6.4% and 2.1%, respectively.

* Airbnb (ABNB) shares were down 3.3%. The Spanish government has ordered the vacation rental company to block more than 65,000 listings for allegedly violating rules set for vacation or temporary housing rentals, the Ministry of Social Rights and Consumption said Monday.

* Paramount Global's (PARA) efforts to settle President Donald Trump's lawsuit against its CBS News unit have caused several US senators to seek information about possible violations of a federal bribery statute in connection with the company's desire to complete a merger with Skydance Media, The Wall Street Journal reported Tuesday.