ORIC Pharmaceuticals Announces Promising Phase 1b Trial Results for ORIC-944 in Combination with AR Inhibitors in mCRPC Patients

Reuters

2025/05/29

ORIC Pharmaceuticals Announces Promising Phase 1b Trial Results for ORIC-944 in Combination with AR Inhibitors in mCRPC Patients

ORIC Pharmaceuticals, Inc. has announced promising preliminary efficacy and safety data from its ongoing Phase 1b trial of ORIC-944. The trial involves combining ORIC-944 with androgen receptor inhibitors in patients with metastatic castration-resistant prostate cancer (mCRPC). The study reported a 59% PSA50 response rate, with a confirmed rate of 47%, and a 24% confirmed PSA90 response rate. PSA responses were consistent across all dose levels and in combination with both apalutamide and darolutamide. The safety profile of the drug combination was compatible with long-term dosing, with most adverse events being Grade 1 or 2. ORIC Pharmaceuticals also announced a $125 million financing, extending its cash runway into the second half of 2027. The company plans to initiate its first global registrational trial in the first half of 2026.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Oric Pharmaceuticals Inc published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9459430-en) on May 28, 2025, and is solely responsible for the information contained therein.

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The trial involves combining ORIC-944 with androgen receptor inhibitors in patients with metastatic castration-resistant prostate cancer (mCRPC). The study reported a 59% PSA50 response rate, with a confirmed rate of 47%, and a 24% confirmed PSA90 response rate. PSA responses were consistent across all dose levels and in combination with both apalutamide and darolutamide. The safety profile of the drug combination was compatible with long-term dosing, with most adverse events being Grade 1 or 2. ORIC Pharmaceuticals also announced a $125 million financing, extending its cash runway into the second half of 2027. The company plans to initiate its first global registrational trial in the first half of 2026.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Oric Pharmaceuticals Inc published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9459430-en) on May 28, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"IE00B3QW5Z07.USD","symbol_name":"GUINNESS GLOBAL MONEY MANAGERS \"C\" (USD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250528:nNDL76LT4n:1","article_id":"2539406028","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2539406028","pubTimestamp":1748462744,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"ORIC Pharmaceuticals Announces Promising Phase 1b Trial Results for ORIC-944 in Combination with AR Inhibitors in mCRPC Patients. 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The trial involves combining ORIC-944 with androgen receptor inhibitors in patients with metastatic castration-resistant prostate cancer (mCRPC). The study reported a 59% PSA50 response rate, with a confirmed rate of 47%, and a 24% confirmed PSA90 response rate. PSA responses were consistent across all dose levels and in combination with both apalutamide and darolutamide. The safety profile of the drug combination was compatible with long-term dosing, with most adverse events being Grade 1 or 2. ORIC Pharmaceuticals also announced a $125 million financing, extending its cash runway into the second half of 2027. The company plans to initiate its first global registrational trial in the first half of 2026.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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