At the start of each week, I like to look at ASIC's short position report to find out which shares are being targeted by short sellers.

This is because I believe it is well worth keeping a close eye on short interest levels as high levels can sometimes be a sign that something isn't quite right with a company.

With that in mind, here are the 10 most shorted shares on the ASX this week according to ASIC:

• Boss Energy Ltd (ASX: BOE) continues its long run as the most shorted ASX share with short interest of 21.2%. This is down week on week once again. Short sellers aren't giving up on this one US President Donald Trump signing an order to boost the uranium industry.
• Paladin Energy Ltd (ASX: PDN) has seen its short interest ease week on week to 15.3%. It is another uranium miner that short sellers are betting heavily against.
• Mineral Resources Ltd (ASX: MIN) has short interest of 13.9%, which is down since last week. The mining and mining services shares have been crushed since this time last year due to weak commodity prices and concerns over its balance sheet.
• Liontown Resources Ltd (ASX: LTR) has short interest of 12.7%, which is down slightly from last week. Weak lithium spot prices have weighed heavily on its shares.
• Pilbara Minerals Ltd (ASX: PLS) has seen its short interest ease to 12.1%. This is yet another lithium miner that short sellers have successfully being targeting.
• IDP Education Ltd (ASX: IEL) has 12% of its shares held short, which is down week on week. This student placement and language testing company's shares are down 50% since this time last year amid concerns over significant industry headwinds.
• Deep Yellow Limited (ASX: DYL) has 11% of its shares held short, which is down week on week again. It is another uranium stock that short sellers have been successfully targeting. Its shares are down 20% over the past 12 months.
• Polynovo Ltd (ASX: PNV) has 10.6% of its shares held short, which is down week on week. This medical device company's growth in 2025 has been below expectations.
• Karoon Energy Ltd (ASX: KAR) has short interest of 10.1%, which is flat since last week. This may be due to concerns over oil and gas demand.
• Lifestyle Communities Ltd (ASX: LIC) has returned to the top ten with short interest of 10%. Investors appear to be betting on negative media coverage causing headwinds for this retirement living developer.