Prothena Corporation plc has announced the advancement of several clinical trials across its portfolio. Roche, in collaboration with Prothena, will progress prasinezumab into Phase 3 development for early-stage Parkinson's disease. Additionally, Prothena anticipates the release of initial data in August from its Phase 1 ASCENT clinical trials for the PRX012 program, targeting Alzheimer's disease. Looking ahead, Novo Nordisk plans to share data from its Phase 2 clinical trial evaluating coramitug for ATTR-CM in the latter half of 2025. Furthermore, Prothena expects to complete a Phase 1 clinical trial for PRX019 in collaboration with Bristol Myers Squibb by 2026, and Bristol Myers Squibb aims to conclude a Phase 2 TargetTau-1 clinical trial evaluating BMS-986446 in Alzheimer's disease by 2027.