Wall Street's main indexes ticked up on Wednesday as Nvidia rocketed to a $4 trillion valuation, while investors took in their stride President Donald Trump's latest tariff salvo. .N

At 13:30 EDT, the Dow Jones Industrial Average .DJI was up 0.23% at 44,341.96.The S&P 500 .SPX was up 0.32% at 6,245.47, and the Nasdaq Composite .IXIC was up 0.62% at 20,544.92.

The top three S&P 500 .PG.INX percentage gainers:

** AES Corp AES.N, up 16.9%

** Boeing Co BA.N, up 5.1%

** Vistra Corp VST.N, up 4.2%

The top three S&P 500 .PL.INX percentage losers:

** Fair Isaac Corp FICO.N, down 5.6%

** Hershey Co HSY.N, down 4.7%

** Altria Group Inc MO.N, down 4.3%

The top three NYSE .PG.N percentage gainers:

** Sunlands Technology Group STG.N, up 26.3%

** Grove Collaborative Holdings Inc GROV.N, up 24.8%

** Offerpad Solutions Inc OPAD.N, up 19.8%

The top three NYSE .PL.N percentage losers:

** Vertical Aerospace Ltd EVTL.N, down 28.8%

** CNFinance Holdings Ltd CNF.N, down 18.8%

** WPP PLC WPP.N, down 17.4%

The top three Nasdaq .PG.O percentage gainers:

** SU Group Holdings Ltd SUGP.OQ, up 168.1%

** Evoke Pharma Inc EVOK.OQ, up 153.8%

** Basel Medical Group Ltd BMGL.OQ, up 98.9%

The top three Nasdaq .PL.O percentage losers:

** Park Ha Biological Technology Co Ltd PHH.OQ, down 62.4%

** Rxsight Inc RXST.OQ, down 37.9%

** Wag! Group Co PET.OQ, down 30.1%

** British American Tobacco PLC <BTI.N>:BUZZ - Jefferies terms BAT as 'top pick' among global tobacco companies, shares jump 3.3% nL6N3T60EM

** Novo Nordisk A/S <NVO.N>:

** Sanofi SA <SNY.PA>:

** AstraZeneca PLC <NVO.O>:BUZZ - European pharmaceuticals fall on looming U.S. tariffs nL8N3T60CP

** Verona Pharma PLC <VRNA.O>:BUZZ - Hits record high after Merck's $10 billion acquisition nL4N3T619N

** Bloom Energy Corp <BE.N>:BUZZ - Jumps after J.P.Morgan upgrades to 'overweight' nL4N3T61B4

** Newmont Corp <NEM.N>:

** Barrick Mining Corp <B.N>:

** Gold Fields Ltd <GFI.N>:

** Harmony Gold Mining Co Ltd <HMY.N>:

BUZZ - Gold miners down as bullion prices edge lower on strong US dollar nL4N3T60RJ

** AES Corp <AES.N>:BUZZ - Jumps on report of potential sale efforts nL4N3T60RI

** UnitedHealth Group Inc <UNH.N>:BUZZ - Falls after WSJ report on DOJ investigating co's Medicare billing nL4N3T614G

** Cogent Biosciences Inc <COGT.O>:BUZZ - Slips after upsized $200 mln equity offering nL6N3T60HB

** Starbucks Corp <SBUX.O>:BUZZ - Rises on CNBC report China business attracts bids for up to $10 billion valuation nL6N3T60H0

** PVH Corp <PVH.N>:BUZZ - Slips as TD Cowen downgrades to 'hold' nL6N3T60HR

** NextEra Energy Inc <NEE.N>:BUZZ - Scotiabank says NextEra Energy's outlook safe from impact of Trump's bill nL4N3T60U6

** Norfolk Southern Corp <NSC.N>:BUZZ - Inches down after Citi cuts to 'neutral' on valuation nL4N3T60W9

** T-Mobile US Inc <TMUS.O>:BUZZ - Falls as KeyBanc downgrades to 'underweight' nL4N3T60WA

** FVCBankcorp Inc <FVCB.O>:BUZZ - Gets 'overweight' rating as Piper Sandler resumes coverage nL4N3T51BA

** Vertical Aerospace Ltd <EVTL.N>:BUZZ - Tumbles on $60 mln stock sale nL6N3T60KL

** Microsoft Corp <MSFT.O>:BUZZ - Oppenheimer upgrades Microsoft to 'outperform' on AI potential nL4N3T60XK

** Charles River Laboratories International Inc <CRL.N>:

** Illumina Inc <ILMN.O>:

** Hologic Inc <HOLX.O>:BUZZ - Citi flags uncertainty in life science sector as funding shifts and tariffs bite nL4N3T617E

** Honeywell International Inc <HON.O>:BUZZ - Barclays lifts Honeywell PT citing short-cycle industrial demand prospects nL4N3T60Y0

** Venture Global Inc <VG.N>:BUZZ - Gains on agreement to supply more LNG to German firm from CP2 project nL4N3T615C

** XPO Inc <XPO.N>:BUZZ - Falls after Citi downgrades to 'neutral' nL4N3T60XC

** Rockwell Automation Inc <ROK.N>:BUZZ - Barclays lifts Rockwell PT on growth opportunities nL4N3T50U5

** Boeing Co <BA.N>:BUZZ - Up; Susquehanna lifts PT after June deliveries rise nL4N3T6142

** Walt Disney Co <DIS.N>:

** Warner Bros Discovery Inc <WBD.O>:

** Paramount Global <PARA.O>:

BUZZ - Ad spend in Q2 strong with possible upside from TV pricing, Barclays says nL4N3T60WW

** Rhythm Pharmaceuticals Inc <RYTM.O>:BUZZ - Hits record high as drug reduces weight in rare type of obesity nL4N3T6156

** Ball Corp <BALL.N>:BUZZ - Slips after BofA downgrades to 'neutral' nL6N3T60LK

** Nvidia Corp <NVDA.O>:BUZZ - Becomes first public company in world to hit $4 trillion market value nL4N3T615N

** Jasper Therapeutics Inc <JSPR.O>:BUZZ - Falls after halting clinical programs nL6N3T60LY

** Mobileye Global Inc <MBLY.O>:BUZZ - Shares turn south after unveiling Intel's $900 mln stake sale plans nL6N3T60OB

** Eli Lilly and Co <LLY.N>:BUZZ - Climbs as FDA approves gradual dosing for Alzheimer's drug nL4N3T6181

** Canopy Growth Corp <CGC.O>:BUZZ - Gains after financial leadership reshuffle nL4N3T618H

** Arm Holdings Inc <ARM.O>:BUZZ - Stock rises on data center growth nL6N3T60O4

** Alphabet Inc <GOOGL.O>:BUZZ - Shares rise as executive paints bright AI invesments outlook nL6N3T60P3

** Warner Music Group Corp <WMG.O>:BUZZ - Gains after BofA upgrade nL4N3T61BM

** Super Micro Computer Inc <SMCI.O>:BUZZ - BofA resumes Super Micro Computer coverage with 'underperform' rating nL4N3T61CE

** GeneDx Holdings Corp <WGS.O>:BUZZ - Rises after Piper Sandler initiates coverage with 'overweight' rating nL4N3T61D8

(Compiled by Rajarshi Roy and Apratim Sarkar)

((Rajarshi.Roy@thomsonreuters.com))