Wall Street's main indexes led a global selloff on Friday as new U.S. tariffs on dozens of trading partners weighed on sentiment, while a weaker-than-expected payrolls report added to risk aversion. .N

At 13:30 EDT, the Dow Jones Industrial Average .DJI was down 1.44% at 43,499.66.The S&P 500 .SPX was down 1.74% at 6,228.16, and the Nasdaq Composite .IXIC was down 2.34% at 20,628.51.

The top three S&P 500 .PG.INX percentage gainers:

** Monolithic Power Systems Inc MPWR.OQ, up 9.9%

** Align Technology Inc ALGN.OQ, up 6.9%

** First Solar Inc FSLR.OQ, up 5.4%

The top three S&P 500 .PL.INX percentage losers:

** Eastman Chemical Co EMN.N, down 20.9%

** Coinbase Global Inc COIN.OQ, down 15.9%

** Ingersoll Rand Inc IR.N, down 11.5%

The top three NYSE .PG.N percentage gainers:

** Workiva Inc WK.N, up 26.1%

** Reddit Inc RDDT.N, up 20.8%

** Bio Rad Laboratories Inc BIO.N, up 17.8%

The top three NYSE .PL.N percentage losers:

** Fluor Corp FLR.N, down 29.2%

** Douglas Elliman Inc DOUG.N, down 25.3%

** MagnaChip Semiconductor Corp MX.N, down 23.9%

The top three Nasdaq .PG.O percentage gainers:

** LOBO EV Technologies Ltd LOBO.OQ, up 197.6%

** Performant Healthcare Inc PHLT.OQ, up 114.9%

** Fundamental Global Inc FGF.OQ, up 54.5%

The top three Nasdaq .PL.O percentage losers:

** Safe & Green Holdings Corp SGBX.OQ, down 53.8%

** Neurosense Therapeutics Ltd NRSN.OQ, down 40.0%

** Zynex Inc ZYXI.OQ, down 39.5%

** Novo Nordisk A/S <NVO.N>:

** AstraZeneca PLC <AZN.O>:

** Sanofi SA <SNY.O>:

** GSK PLC <GSK.N>:BUZZ - European pharma falls after Trump ramps up pressure to cut US drug prices nL6N3TT09S

** Reddit Inc <RDDT.N>:BUZZ - Shares light up premarket after blowout Q3 outlook nL4N3TT0N3

** Chevron Corp <CVX.N>:BUZZ - Gains on Q2 profit beat nL4N3TT0S7

** Roku Inc <ROKU.O>:BUZZ - Dips despite beating Q2 estimates nL6N3TT0CZ

** Figma Inc <FIG.N>:BUZZ - Extends gains after stellar public debut nL6N3TT0EC

** Eastman Chemical Co <EMN.N>:BUZZ - Falls on downbeat Q3 profit expectations nL4N3TT1IP

** Eli Lilly and Co <LLY.N>:BUZZ - Rises on report of Medicare, Medicaid coverage for weight-loss drugs nL4N3TT0W4

** Exxon Mobil Corp <XOM.N>:BUZZ - Gains after Q2 profit beat nL4N3TT0SL

** Kimberly-Clark Corp <KMB.O>:BUZZ - Rises after strong quarterly sales growth nL4N3TT1FN

** Moderna Inc <MRNA.O>:BUZZ - Falls after lowering 2025 sales forecast nL4N3TT0ZF

** Hims & Hers Health Inc <HIMS.N>:BUZZ - Slips on report of Medicare, Medicaid coverage for weight-loss drugs nL4N3TT1PL

** CNH Industrial NV <CNH.N>:BUZZ - Rises after upbeat second-quarter results nL4N3TT17A

** Orchestra BioMed Holdings Inc <OBIO.O>:BUZZ - Drops after $40 mln equity raise nL6N3TT0IN

** Newmont Corp <NEM.N>:BUZZ - Gains on $100 million payment from China's Zijin Mining nL4N3TT180

** LyondellBasell Industries NV <LYB.N>:BUZZ - Falls on Q2 profit miss nL4N3TT189

** Imperial Oil Corp <IMO.TO>:BUZZ - Falls on Q2 profit drop nL4N3TT1HK

** WW Grainger Inc <GWW.N>:BUZZ - Slumps after trimming annual profit outlook nL4N3TT1HL

** Dominion Energy Inc <D.N>:BUZZ - Gains on Q2 revenue and profit beat nL4N3TT1IY

** JPMorgan Chase &amp; Co <JPM.N>:

** Wells Fargo &amp; Co <WFC.N>:

** Goldman Sachs Group Inc <GS.N>:

** Morgan Stanley <MS.N>:

BUZZ - Economically sensitive bank stocks slide after data signals slowing labor market nL4N3TT1OS

** D.R. Horton Inc <DHI.N>:

** Pultegroup Inc <PHM.N>:

** Lennar Corp <LEN.N>:

BUZZ - U.S. homebuilders rise as yields tumble after weak jobs report nL6N3TT0LT

(Rajarshi Roy and Parth Chandna)

((Rajarshi.Roy@thomsonreuters.com and Parth.Chandna@thomsonreuters.com))