Pfizer Announces Positive Results from Phase 3 Trial of PADCEV Plus KEYTRUDA for Bladder Cancer Treatment

Reuters

2025/08/12

Pfizer Announces Positive Results from Phase 3 Trial of PADCEV Plus KEYTRUDA for Bladder <a href="https://laohu8.com/S/CTHZ">Cancer Treatment</a>

Pfizer Inc. and Astellas Pharma Inc. have announced positive topline results from the Phase 3 EV-303 clinical trial, also known as KEYNOTE-905. The trial assessed the efficacy of PADCEV™ (enfortumab vedotin), a Nectin-4 directed antibody-drug conjugate, in combination with KEYTRUDA™ (pembrolizumab), a PD-1 inhibitor, as both neoadjuvant and adjuvant treatment compared to surgery alone in patients with muscle-invasive bladder cancer (MIBC) who are ineligible for or declined cisplatin-based chemotherapy. The study demonstrated a clinically meaningful and statistically significant improvement in event-free survival (EFS) and overall survival $(OS)$, with an additional secondary endpoint of pathologic complete response (pCR) rate being met. Details of the findings will be submitted for presentation at an upcoming medical congress and discussed with global health authorities for potential regulatory filings.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Pfizer Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20250812968002) on August 12, 2025, and is solely responsible for the information contained therein.

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The trial assessed the efficacy of PADCEV™ (enfortumab vedotin), a Nectin-4 directed antibody-drug conjugate, in combination with KEYTRUDA™ (pembrolizumab), a PD-1 inhibitor, as both neoadjuvant and adjuvant treatment compared to surgery alone in patients with muscle-invasive bladder cancer (MIBC) who are ineligible for or declined cisplatin-based chemotherapy. The study demonstrated a clinically meaningful and statistically significant improvement in event-free survival (EFS) and overall survival <a href=\"https://laohu8.com/S/OS\">$(OS)$</a>, with an additional secondary endpoint of pathologic complete response (pCR) rate being met. Details of the findings will be submitted for presentation at an upcoming medical congress and discussed with global health authorities for potential regulatory filings.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Pfizer Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20250812968002) on August 12, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU0306806265.USD","symbol_name":"SCHRODER ISF GLOBAL DIVIDEND MAXIMISER \"A\" ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250812:nNDL26RM3K:1","article_id":"2558378643","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2558378643","pubTimestamp":1754991024,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Pfizer Inc. and Astellas Pharma Inc. have announced positive topline results from the Phase 3 EV-303 clinical trial, also known as KEYNOTE-905. The trial assessed the efficacy of PADCEV , a Nectin-4 directed antibody-drug conjugate, in combination with KEYTRUDA , a PD-1 inhibitor, as both neoadjuvant and adjuvant treatment compared to surgery alone in patients with muscle-invasive bladder cancer  who are ineligible for or declined cisplatin-based chemotherapy. The study demonstrated a clinically meaningful and statistically significant improvement in event-free survival  and overall survival , with an additional secondary endpoint of pathologic complete response  rate being met. Details of the findings will be submitted for presentation at an upcoming medical congress and discussed with global health authorities for potential regulatory filings.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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The trial assessed the efficacy of PADCEV™ (enfortumab vedotin), a Nectin-4 directed antibody-drug conjugate, in combination with KEYTRUDA™ (pembrolizumab), a PD-1 inhibitor, as both neoadjuvant and adjuvant treatment compared to surgery alone in patients with muscle-invasive bladder cancer (MIBC) who are ineligible for or declined cisplatin-based chemotherapy. The study demonstrated a clinically meaningful and statistically significant improvement in event-free survival (EFS) and overall survival $(OS)$, with an additional secondary endpoint of pathologic complete response (pCR) rate being met. Details of the findings will be submitted for presentation at an upcoming medical congress and discussed with global health authorities for potential regulatory filings.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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