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International stocks trading in New York closed higher on Wednesday, as the S&P/BNY Mellon index of American depositary receipts gained 0.6% to 222.48.

The European index added 0.2% to 193.78. The Asian index gained 1.0% to 302.85. The Latin American index rose 0.4% to 215.89, while the emerging-markets index gained 1.1% to 498.27.

Switzerland's Addex Therapeutics Ltd. was the biggest leader during the session, jumping 16% to $10.85, and China-based 17 Education & Technology Group Inc. surged 15% to $3.55. Valneva SE, which is based in France, rounded out the top three leaders on Wednesday, with shares jumping 12% to $9.97.

Huize Holding Ltd., based in China, posted the largest decline, cratering 21% to $3.06, followed by shares of China's MOGU Inc., which tumbled 16% to $4.20. Shares of Israel-based Steakholder Foods Ltd. plunged 11% to $4.89.

Data source: Dow Jones Market Data, FactSet

(END) Dow Jones Newswires

September 17, 2025 16:30 ET (20:30 GMT)

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