C4 Therapeutics Showcases Pipeline Progress and Highlights Potential of Cemsidomide and Next-Generation Degrader Programs

Reuters
2025/10/01
C4 <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Showcases Pipeline Progress and Highlights Potential of Cemsidomide and Next-Generation Degrader Programs

C4 Therapeutics Inc. has released a corporate presentation detailing progress across its pipeline of targeted protein degrader medicines. The presentation highlights the advancement of cemsidomide, an IKZF1/3 degrader, which has completed Phase 1 dose escalation in multiple myeloma (MM) and is being evaluated in non-Hodgkin's lymphoma (NHL). Plans include presenting full Phase 1 data at the International Myeloma Society Annual Meeting and initiating a Phase 2 trial of cemsidomide in combination with dexamethasone. Additionally, C4 Therapeutics is utilizing Phase 1 data from its CFT8919 EGFR L858R program to inform global clinical development strategies. The company also announced it will not advance CFT1946 beyond Phase 1 and is seeking partnership opportunities for its BRAF program. The pipeline includes ongoing research targeting pathways such as IL-23/IL-17, Type 1 IFN, MAPK, PI3K/AKT, and NF-κB, with a focus on both oncology and non-oncology indications. C4 Therapeutics continues to pursue collaborations, including a partnership with Pfizer, which will supply elranatamab for an upcoming Phase 1b trial. You can access the full presentation through the link below: [Full Presentation](https://docs.publicnow.com/3CE77CEA538DC349B7BDA965266C8C8BC59AD8B7)

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. C4 Therapeutics Inc. published the original content used to generate this news brief on October 01, 2025, and is solely responsible for the information contained therein.

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