Oct 8 (Reuters) - Wall Street's main indexes edged higher on Wednesday following a brief interruption in a steady rally, as investors awaited fresh clues on the interest-rate trajectory. .N

At 13:30 EDT, the Dow Jones Industrial Average .DJI was up 0.29% at 46,738.86.The S&P 500 .SPX was up 0.58% at 6,753.55, and the Nasdaq Composite .IXIC was up 0.92% at 22,996.44.

The top three S&P 500 .PG.INX percentage gainers:

** Advanced Micro Devices Inc AMD.OQ, up 8.4%

** Arista Networks Inc ANET.N, up 8.3%

** Dell Technologies Inc DELL.N, up 6.8%

The top three S&P 500 .PL.INX percentage losers:

** Fair Isaac Corp FICO.N, down 8.6%

** Warner Bros Discovery Inc WBD.OQ, down 4.2%

** Live Nation Entertainment Inc LYV.N, down 3.5%

The top three NYSE .PG.N percentage gainers:

** NET Power Inc NPWR.N, up 33.3%

** Nouveau Monde Graphite Inc NMG.N, up 16.2%

** Wallbox NV WBX.N, up 15.3%

The top three NYSE .PL.N percentage losers:

** Offerpad Solutions Inc OPAD.N, down 11.3%

** Redwire Corp RDW.N, down 9.0%

** Fair Isaac Corp FICO.N, down 8.6%

The top three Nasdaq .PG.O percentage gainers:

** Xenetic Biosciences Inc XBIO.OQ, up 134.4%

** AlphaTON Capital Corp ATON.OQ, up 92.4%

** Acurx Pharmaceuticals Inc ACXP.OQ, up 70.0%

The top three Nasdaq .PL.O percentage losers:

** Zeta Network Group ZNB.OQ, down 45.7%

** Cenntro Inc (The Corporation) CENN.OQ, down 43.7%

** Envoy Medical Inc COCH.OQ, down 39.6%

** Intel Corp <INTC.O>:BUZZ - Falls; HSBC downgrades stock on weak foundry narrative, lack of deal clarity nL6N3VP0AI

** Newmont Corp <NEM.N>:

** Gold Fields Ltd <GFI.N>:

** AngloGold Ashanti PLC <AU.N>:

** Harmony Gold Mining Co Ltd <HMY.N>:

BUZZ - Gold miners climb as bullion soars past $4,000/oz mark in record rally nL3N3VP0UR

** Confluent Inc <CFLT.O>:BUZZ - Rises on report software maker explores sale nL3N3UX0F1

** FedEx Corp <FDX.N>:BUZZ - Falls after J.P.Morgan downgrades to 'neutral', cuts PT nL6N3VP0EH

** Hecla Mining Co <HL.N>:

** Coeur Mining Inc <CDE.N>:

** Endeavour Silver Corp <EXK.N>:

** Silvercorp Metals Inc <SVM.N>:

BUZZ - Silver miners gain as white metal hits record high on bets of US rate cuts nL3N3VP11P

** Joby Aviation Inc <JOBY.N>:BUZZ - Descends on pricing $514 mln stock offering nL6N3VP0FW

** Schlumberger NV <SLB.N>:BUZZ - Bernstein cuts price target on SLB nL3N3VP0KW

** Zenas Biopharma Inc <ZBIO.O>:BUZZ - Rises on licensing deal for autoimmune drug potentially worth over $2 billion nL3N3VP0KG

** Esperion Therapeutics Inc <ESPR.O>:BUZZ - Tumbles on $75 mln equity raise nL6N3VP0IF

** Phillips 66 <PSX.N>:BUZZ - JP Morgan sees Phillips 66 third-quarter profit below Street nL3N3VP0KX

** CVS Health Corp <CVS.N>:BUZZ - Falls as Amazon Pharmacy to launch electronic kiosks for prescriptions nL3N3VP0MN

** Ford Motor Co <F.N>:BUZZ - Evercore ISI sees Ford supplier's plant fire hitting F-Series output nL3N3VP0LK

** AST Spacemobile Inc <ASTS.O>:BUZZ - Gains after expanding Verizon partnership nL3N3VP0OE

** CervoMed Inc <CRVO.O>:BUZZ - Rises after dementia drug shows promise in mid-stage study nL3N3VP0NP

** Live Nation Entertainment Inc <LYV.N>:BUZZ - Slips after unveiling $1.3 bln convertible bonds sale nL6N3VP0JM

** Werner Enterprises Inc <WERN.O>:BUZZ - Falls after TD Cowen downgrades to "hold" nL3N3VP0PC

** Freshpet Inc <FRPT.O>:BUZZ - At over 2-1/2 year low after BofA cuts rating and price target nL3N3VP0VE

** Werewolf Therapeutics Inc <HOWL.O>:BUZZ - Climbs on FDA's 'fast track' tag for cancer therapy nL3N3VP0QD

** Nano Nuclear Energy Inc <NNE.O>:BUZZ - Drops after $400 mln equity raise nL6N3VP0KN

** Hoth Therapeutics Inc <HOTH.O>:BUZZ - Rises as it expands AI push with Nvidia licenses nL3N3VP0QB

** Elf Beauty Inc <ELF.N>:BUZZ - Up after Morgan Stanley raises PT citing Rhode skincare performance nL6N3VP0MZ

** Equifax Inc <EFX.N>:BUZZ - Rises after slashing credit score pricing nL3N3VP0SD

** Corteva Inc <CTVA.N>:BUZZ - Cuts PT on Corteva following seeds unit spinoff nL6N3VP0LJ

** ArcBest Corp <ARCB.O>:BUZZ - Rises after Citi upgrades to 'buy' nL3N3VP0NU

** Truist Financial Corp <TFC.N>:

** Jefferies Financial Group Inc <JEF.N>:

** Caterpillar Inc <CAT.N>:BUZZ - Lifts Caterpillar's PT on strong margins, steady demand nL3N3VP0RF

** Plug Power Inc <PLUG.O>:BUZZ - Falls on exercising warrants nL3N3VP0SL

** TopBuild Corp <BLD.N>:BUZZ - Rises on closing SPI acquisition nL3N3VP101

** NextDecade Corp <NEXT.O>:BUZZ - Falls after Brent Wahl steps down as CFO nL3N3VP0PY

** Cummins Inc <CMI.N>:BUZZ - Truist, Jefferies raises Cummins PT on strong margin, demand outlook nL3N3VP0VY

** Semtech Corp <SMTC.O>:BUZZ - Slips after $350 mln 0% convertible bonds sale nL6N3VP0TF

** United Rentals Inc <URI.N>:BUZZ - Shares up; Truist raises PT on strong rental rates nL3N3VP0XJ

** Critical Metals Corp <CRML.O>:BUZZ - Surges on offtake agreement with REalloys nL3N3VP0W2

** Dell Technologies Inc <DELL.N>:BUZZ - Rises as analysts hike PT on strong growth forecasts nL6N3VP0UH

** Rio Tinto PLC <RIO.N>:

** BHP Group Ltd <BHP.N>:

** Southern Copper Corp <SCCO.N>:

** Freeport-McMoRan Inc <FCX.N>:

BUZZ - Copper miners gain as red metal darts to 16-month peak on mine disruptions nL3N3VP0YE

** Datadog Inc <DDOG.O>:BUZZ - Rises after Bernstein lifts price target nL3N3VP0YL

** Delta Air Lines Inc <DAL.N>:BUZZ - Revenue, earnings seen rising nL6N3VP0V4

** First Majestic Silver Corp <AG.N>:BUZZ - Jumps as TD Cowen upgrades rating to 'buy' nL3N3VP111

** C.H. Robinson Worldwide Inc <CHRW.O>:BUZZ - Falls after Citi downgrades to 'neutral' nL3N3VP115

** Best Buy Co Inc <BBY.N>:BUZZ - Up after Jefferies raises PT on ads business strength nL6N3VP0WW

** PepsiCo Inc <PEP.O>:BUZZ - Shares slip; Q3 EPS expected to fall from last year nL6N3VP0WL

** AlphaTON Capital Corp <ATON.O>:BUZZ - Skyrockets on blockchain-based cancer drug funding plans nL3N3VP11D

(Rajarshi Roy and Anshi Sancheti)

((Anshi.Sancheti@thomsonreuters.com))