Kelun-Biotech Reports Positive Phase 3 Results for Sacituzumab Tirumotecan in Advanced HR+/HER2- Breast Cancer

Reuters

10/18

Kelun-Biotech Reports Positive Phase 3 Results for Sacituzumab Tirumotecan in Advanced HR+/HER2- Breast Cancer

Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. has announced positive results from the Phase 3 OptiTROP-Breast02 clinical study evaluating sacituzumab tirumotecan (sac-TMT), a TROP2-directed antibody-drug conjugate, in patients with previously treated locally advanced or metastatic hormone receptor-positive (HR+)/HER2-negative breast cancer. The results were presented at the 2025 European Society for Medical Oncology (ESMO) Congress in Berlin, Germany. The study demonstrated that sac-TMT achieved statistically significant and clinically meaningful improvement in progression-free survival compared to chemotherapy, with benefits observed across all predefined subgroups and independent of HER2 status. Sac-TMT also showed a trend toward overall survival benefit and had a favorable and manageable safety profile with no new safety signals reported. Additional Phase III clinical studies of sac-TMT as monotherapy and in combination with pembrolizumab are ongoing globally and in China.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN01484) on October 18, 2025, and is solely responsible for the information contained therein.

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The results were presented at the 2025 European Society for Medical Oncology (ESMO) Congress in Berlin, Germany. The study demonstrated that sac-TMT achieved statistically significant and clinically meaningful improvement in progression-free survival compared to chemotherapy, with benefits observed across all predefined subgroups and independent of HER2 status. Sac-TMT also showed a trend toward overall survival benefit and had a favorable and manageable safety profile with no new safety signals reported. Additional Phase III clinical studies of sac-TMT as monotherapy and in combination with pembrolizumab are ongoing globally and in China.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN01484) on October 18, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU0196878994.USD","symbol_name":"MANULIFE GF CHINA VALUE \"AA\" (USD) INC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251018:nNDL8byc79:1","article_id":"2576017137","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2576017137","pubTimestamp":1760798574,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. has announced positive results from the Phase 3 OptiTROP-Breast02 clinical study evaluating sacituzumab tirumotecan , a TROP2-directed antibody-drug conjugate, in patients with previously treated locally advanced or metastatic hormone receptor-positive (HR+)/HER2-negative breast cancer. 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The results were presented at the 2025 European Society for Medical Oncology (ESMO) Congress in Berlin, Germany. The study demonstrated that sac-TMT achieved statistically significant and clinically meaningful improvement in progression-free survival compared to chemotherapy, with benefits observed across all predefined subgroups and independent of HER2 status. Sac-TMT also showed a trend toward overall survival benefit and had a favorable and manageable safety profile with no new safety signals reported. Additional Phase III clinical studies of sac-TMT as monotherapy and in combination with pembrolizumab are ongoing globally and in China.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN01484) on October 18, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"dataReport,express","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}