DaVita Inc. has announced the launch of two new initiatives, MODEL and MEMOIRS, aimed at enhancing the understanding of middle-molecule removal in dialysis treatments for patients with end stage kidney disease (ESKD). These initiatives will collectively involve approximately 9,000 adults over the next two years. The MODEL initiative is a quality improvement project evaluating the survival of U.S. patients treated with medium cut-off dialyzers, while the MEMOIRS survey is a prospective cohort study comparing patient-reported outcomes between treatments using medium cut-off and high-flux dialyzers. The studies seek to generate first-of-its-kind U.S. data on the clinical outcomes and quality of life impacts of middle-molecule clearance. The results of these initiatives have not yet been presented.