Aldeyra Therapeutics Reports Positive Phase 2 Results for ADX-629 in Alcohol-Associated Hepatitis

Reuters

10/28

Aldeyra <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports Positive Phase 2 Results for ADX-629 in Alcohol-Associated Hepatitis

Aldeyra Therapeutics Inc. announced positive results from a Phase 2 clinical trial evaluating ADX-629, an investigational RASP modulator, in patients with mild to moderate alcohol-associated hepatitis. The single-arm, multicenter study involved oral administration of ADX-629 for one month in four patients. Statistically significant improvements were observed in markers of hepatic function and inflammation, including the Model for End-Stage Liver Disease (MELD) score (P=0.001), triglyceride levels (P<0.0001), and C-Reactive Protein levels (P<0.0001). No serious adverse events were reported, and no adverse events were considered related to ADX-629. The company indicated that these positive results mark the culmination of clinical proof-of-concept for ADX-629, and that further details will be shared in the future. Aldeyra also announced a strategic shift in its pipeline to focus on next-generation RASP modulators, specifically ADX-248 and ADX-246, for the treatment of immune-mediated diseases.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Aldeyra Therapeutics Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251028764760) on October 28, 2025, and is solely responsible for the information contained therein.

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The single-arm, multicenter study involved oral administration of ADX-629 for one month in four patients. Statistically significant improvements were observed in markers of hepatic function and inflammation, including the Model for End-Stage Liver Disease (MELD) score (P=0.001), triglyceride levels (P&lt;0.0001), and C-Reactive Protein levels (P&lt;0.0001). No serious adverse events were reported, and no adverse events were considered related to ADX-629. The company indicated that these positive results mark the culmination of clinical proof-of-concept for ADX-629, and that further details will be shared in the future. Aldeyra also announced a strategic shift in its pipeline to focus on next-generation RASP modulators, specifically ADX-248 and ADX-246, for the treatment of immune-mediated diseases.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Aldeyra Therapeutics Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251028764760) on October 28, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4139","symbol_name":"生物科技","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251028:nNDLPSv2P:1","article_id":"2578195868","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2578195868","pubTimestamp":1761649418,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Aldeyra Therapeutics Inc. announced positive results from a Phase 2 clinical trial evaluating ADX-629, an investigational RASP modulator, in patients with mild to moderate alcohol-associated hepatitis. The single-arm, multicenter study involved oral administration of ADX-629 for one month in four patients. Statistically significant improvements were observed in markers of hepatic function and inflammation, including the Model for End-Stage Liver Disease  score , triglyceride levels , and C-Reactive Protein levels . No serious adverse events were reported, and no adverse events were considered related to ADX-629. The company indicated that these positive results mark the culmination of clinical proof-of-concept for ADX-629, and that further details will be shared in the future. 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Statistically significant improvements were observed in markers of hepatic function and inflammation, including the Model for End-Stage Liver Disease (MELD) score (P=0.001), triglyceride levels (P<0.0001), and C-Reactive Protein levels (P<0.0001). No serious adverse events were reported, and no adverse events were considered related to ADX-629. The company indicated that these positive results mark the culmination of clinical proof-of-concept for ADX-629, and that further details will be shared in the future. Aldeyra also announced a strategic shift in its pipeline to focus on next-generation RASP modulators, specifically ADX-248 and ADX-246, for the treatment of immune-mediated diseases.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Aldeyra Therapeutics Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251028764760) on October 28, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"dataReport,express","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}