Acurx Pharmaceuticals Inc. has announced new data on its DNA pol IIIC inhibitor antibiotics, including its Phase 3-ready candidate ibezapolstat. The results were presented at the Infectious Diseases Society of America $(IDSA)$ IDWeek 2025 Scientific Conference. The presentation included updates on ibezapolstat's selective antibacterial activity in the gut, which spares beneficial bile acid-metabolizing bacteria and may contribute to reduced recurrence of C. difficile infection. Additionally, new colonic microbiome data from a mouse infection model suggest that microbiome selectivity may be a class effect among DNA pol IIIC inhibitors, when compared to the comparator antibiotic linezolid.
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