BridgeBio Oncology Therapeutics Inc. has announced two upcoming poster presentations at the San Antonio Breast Cancer Symposium (SABCS), to be held December 9-12, 2025. The company will share new data on BBO-10203, a first-in-class, orally bioavailable, selective breaker of the RAS:PI3Kα interaction. The first poster will present pre-clinical results showing that BBO-10203 inhibits tumor growth alone and in combination with fulvestrant or ribociclib in breast cancer models, without inducing hyperglycemia. The second poster will provide details on BREAKER-101, an ongoing phase 1a/1b open-label clinical trial evaluating the safety, tolerability, pharmacokinetics, and efficacy of BBO-10203 in patients with advanced solid tumors. The results from these studies will be presented at the symposium and have not yet been publicly disclosed.