Dianthus Therapeutics Announces Positive Phase 2 Claseprubart Data in Myasthenia Gravis

Reuters

2025/10/30

Dianthus <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Announces Positive Phase 2 Claseprubart Data in Myasthenia Gravis

Dianthus Therapeutics Inc. has announced new data from its Phase 2 MaGic trial evaluating claseprubart in patients with generalized Myasthenia Gravis (gMG). The results, including new open-label extension data, were presented during the Myasthenia Gravis Foundation of America (MGFA) Scientific Session at the 2025 American Association of Neuromuscular and Electromagnetic Medicine (AANEM) Annual Meeting. The company highlighted the potential of 300mg/2mL Q4W dosing of claseprubart and plans to initiate a Phase 3 trial in 2026. The upcoming Phase 3 study will include two claseprubart treatment arms (300mg/2mL Q2W and 300mg/2mL Q4W) versus placebo, with a QMG ≥10 screening criterion. Dianthus also presented preclinical in vitro data suggesting efficacy benefits of upstream (active C1s) inhibition with claseprubart compared to downstream (C5) inhibition. Further details and a replay of the virtual industry forum are available on the company's website.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Dianthus Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9564746-en) on October 29, 2025, and is solely responsible for the information contained therein.

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ID: GNW9564746-en) on October 29, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>","source":null,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Dianthus Therapeutics Announces Positive Phase 2 Claseprubart Data in Myasthenia Gravis</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nDianthus Therapeutics Announces Positive Phase 2 Claseprubart Data in Myasthenia Gravis\n</h2>\n\n<h4 class=\"meta\">\n\n\n<a class=\"head\" href=\"https://laohu8.com/wemedia/1032215980\">\n\n\n<div class=\"h-thumb\" style=\"background-image:url(https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">Reuters </p>\n<p class=\"h-time\">2025-10-30 03:30</p>\n</div>\n\n</a>\n\n\n</h4>\n\n</header>\n<article>\n<html xmlns=\"http://www.w3.org/1999/xhtml\" xmlns:newsg2=\"http://iptc.org/std/nar/2006-10-01/\" xmlns:xhtml=\"http://www.w3.org/1999/xhtml\"><head><title>\n      Dianthus <a href=\"https://laohu8.com/S/LENZ\">Therapeutics</a> Announces Positive Phase 2 Claseprubart Data in Myasthenia Gravis\n    </title></head><body><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<p>\n        <a href=\"https://laohu8.com/S/DNTH\">Dianthus Therapeutics Inc.</a> has announced new data from its Phase 2 MaGic trial evaluating claseprubart in patients with generalized Myasthenia Gravis (gMG). The results, including new open-label extension data, were presented during the Myasthenia Gravis Foundation of America (MGFA) Scientific Session at the 2025 American Association of Neuromuscular and Electromagnetic Medicine (AANEM) Annual Meeting. The company highlighted the potential of 300mg/2mL Q4W dosing of claseprubart and plans to initiate a Phase 3 trial in 2026. The upcoming Phase 3 study will include two claseprubart treatment arms (300mg/2mL Q2W and 300mg/2mL Q4W) versus placebo, with a QMG ≥10 screening criterion. Dianthus also presented preclinical in vitro data suggesting efficacy benefits of upstream (active C1s) inhibition with claseprubart compared to downstream (C5) inhibition. Further details and a replay of the virtual industry forum are available on the company's website.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Dianthus Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9564746-en) on October 29, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4588","symbol_name":"碎股","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251029:nNDL8c64qp:1","article_id":"2579180997","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2579180997","pubTimestamp":1761766226,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Dianthus Therapeutics Inc. has announced new data from its Phase 2 MaGic trial evaluating claseprubart in patients with generalized Myasthenia Gravis . The results, including new open-label extension data, were presented during the Myasthenia Gravis Foundation of America  Scientific Session at the 2025 American Association of Neuromuscular and Electromagnetic Medicine  Annual Meeting. The company highlighted the potential of 300mg/2mL Q4W dosing of claseprubart and plans to initiate a Phase 3 trial in 2026. The upcoming Phase 3 study will include two claseprubart treatment arms  versus placebo, with a QMG ≥10 screening criterion. Dianthus also presented preclinical in vitro data suggesting efficacy benefits of upstream  inhibition with claseprubart compared to downstream  inhibition. Further details and a replay of the virtual industry forum are available on the company's website.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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The results, including new open-label extension data, were presented during the Myasthenia Gravis Foundation of America (MGFA) Scientific Session at the 2025 American Association of Neuromuscular and Electromagnetic Medicine (AANEM) Annual Meeting. The company highlighted the potential of 300mg/2mL Q4W dosing of claseprubart and plans to initiate a Phase 3 trial in 2026. The upcoming Phase 3 study will include two claseprubart treatment arms (300mg/2mL Q2W and 300mg/2mL Q4W) versus placebo, with a QMG ≥10 screening criterion. Dianthus also presented preclinical in vitro data suggesting efficacy benefits of upstream (active C1s) inhibition with claseprubart compared to downstream (C5) inhibition. Further details and a replay of the virtual industry forum are available on the company's website.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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