Summit Therapeutics Reports Phase III Success for Ivonescimab in EGFR-Mutated NSCLC

Reuters

2025/10/31

<a href="https://laohu8.com/S/SMMT">Summit</a> <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports Phase III Success for Ivonescimab in EGFR-Mutated NSCLC

Summit Therapeutics Inc. has announced that data from the Phase III HARMONi-A trial, evaluating the investigational bispecific antibody ivonescimab in combination with chemotherapy versus chemotherapy alone, will be presented at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC 2025) on November 7, 2025. The HARMONi-A study, conducted in China and sponsored by Akeso, Inc., focused on patients with EGFR-mutated, locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who had progressed after EGFR tyrosine kinase inhibitor (TKI) treatment. The trial demonstrated a statistically significant overall survival benefit for the ivonescimab regimen compared to standard care. Ivonescimab has not been approved by regulatory authorities in Summit's license territories, including the United States and Europe.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Summit Therapeutics Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251031005548) on October 31, 2025, and is solely responsible for the information contained therein.

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The HARMONi-A study, conducted in China and sponsored by Akeso, Inc., focused on patients with EGFR-mutated, locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who had progressed after EGFR tyrosine kinase inhibitor (TKI) treatment. The trial demonstrated a statistically significant overall survival benefit for the ivonescimab regimen compared to standard care. Ivonescimab has not been approved by regulatory authorities in Summit's license territories, including the United States and Europe.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Summit Therapeutics Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251031005548) on October 31, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU0348784397.USD","symbol_name":"ALLIANZ ORIENTAL INCOME \"A\" (USD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251031:nNDL9L1lMc:1","article_id":"2579746333","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2579746333","pubTimestamp":1761908446,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Summit Therapeutics Inc. has announced that data from the Phase III HARMONi-A trial, evaluating the investigational bispecific antibody ivonescimab in combination with chemotherapy versus chemotherapy alone, will be presented at the Annual Meeting of the Society for Immunotherapy of Cancer  on November 7, 2025. The HARMONi-A study, conducted in China and sponsored by Akeso, Inc., focused on patients with EGFR-mutated, locally advanced or metastatic non-squamous non-small cell lung cancer  who had progressed after EGFR tyrosine kinase inhibitor  treatment. The trial demonstrated a statistically significant overall survival benefit for the ivonescimab regimen compared to standard care. Ivonescimab has not been approved by regulatory authorities in Summit's license territories, including the United States and Europe.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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