Heron Therapeutics reported net revenue of $38.2 million for the third quarter of 2025, bringing year-to-date net revenue to $114.3 million, a 10.4% increase compared to the prior year period. The company reaffirmed its 2025 full-year net revenue guidance of $153 million to $163 million and adjusted EBITDA guidance of $9.0 million to $13.0 million. ZYNRELEF net revenue grew 49% in the third quarter of 2025 compared to the same period in 2024, supported by the launch of the Vial Access Needle and an enhanced distributor incentive program. APONVIE net revenue increased 173% year-over-year for the quarter, driven by expanded adoption and a newly launched dedicated sales team. The Acute Care franchise achieved 67.2% revenue growth year-over-year in the third quarter and 69.2% growth for the first nine months of 2025.