Quoin Pharmaceuticals Ltd. has announced the successful achievement of target loading concentrations for its two proprietary topical rapamycin delivery technologies. The company has formulated a topical lotion with a 4% w/w rapamycin concentration and a dermal patch system with a 5% w/w concentration. These developments mark a significant milestone for Quoin's topical rapamycin programs. The company plans to begin manufacturing clinical trial and stability batches in the fourth quarter of 2025, with clinical testing set to commence in the first half of 2026. Initial clinical indications will include Microcystic Lymphatic Malformations and Venous Malformations, for which no FDA-approved treatments currently exist. The results have been announced by the company and clinical testing will be conducted in the future.