Acurx Pharmaceuticals Inc. has announced the publication of results from a scientific collaboration with Leiden University Medical Center (LUMC), detailing structural biology research on its lead antibiotic candidate, ibezapolstat. The study, published in Nature Communications, demonstrates for the first time the binding of ibezapolstat, a DNA pol IIIC inhibitor, to its bacterial target. Ibezapolstat has shown 96% initial cure with no recurrence in Phase 2 clinical trials for C. difficile infection and is now ready for Phase 3 trials in the U.S. and EU. The company is also advancing new DNA pol IIIC inhibitor antibiotics for other multi-drug-resistant Gram-positive pathogens. The results have already been published and presented.