Wall Street's main indexes fell on Thursday with investors cautious ahead of indications on the U.S. economy and the monetary policy path after President Donald Trump signed a bill ending the longest government shutdown in the country's history. .N

At 13:30 EST, the Dow Jones Industrial Average .DJI was down 1.17% at 47,688.22. The S&P 500 .SPX was down 1.52% at 6,746.92, and the Nasdaq Composite .IXIC was down 2.38% at 22,849.82.

The top three S&P 500 .PG.INX percentage gainers:

** Albemarle Corp ALB.N, up 4.3%

** LyondellBasell Industries NV LYB.N, up 4.1%

** Cisco Systems Inc CSCO.OQ, up 3.8%

The top three S&P 500 .PL.INX percentage losers:

** Robinhood Markets Inc HOOD.OQ, down 8.6%

** Walt Disney Co DIS.N, down 7.8%

** Tesla Inc TSLA.OQ, down 7.5%

The top three Nasdaq .PG.O percentage gainers:

** Nuvve Holding Corp NVVE.OQ, up 262.1%

** Mersana Therapeutics Inc MRSN.OQ, up 210.0%

** TNL Mediagene TNMG.OQ, up 57.7%

The top three Nasdaq .PL.O percentage losers:

** Korro Bio Inc KRRO.OQ, down 80.2%

** Kaixin Holdings KXIN.OQ, down 66.1%

** Applied Therapeutics Inc APLT.OQ, down 65.6%

** Baidu Inc BIDU.O:BUZZ - Hong Kong stock climbs on new AI processors, supercomputing products nL1N3WP06I

** Merck & Co Inc MRK.N:BUZZ - Up in early trade after Q3 beat, narrowing outlook nL8N3WP0BT

** Walt Disney Co DIS.N:BUZZ - Falls as Q4 revenue misses estimates nL6N3WP0V0

** Cellebrite DI Ltd CLBT.O:BUZZ - Surges after quarterly revenue beat, raised guidance nL6N3WP0KW

** Edgewell Personal Care Co EPC.N:BUZZ - Slips after Q4 profit miss nL6N3WP0QE

** Newmont Corp NEM.N:

** Gold Fields Ltd GFI.N:

** AngloGold Ashanti PLC AU.N:

** Sibanye Stillwater Ltd SBSW.N:

BUZZ - Gold miners rise on US debt concerns, Fed rate cut expectations nL6N3WP0LY

** Cisco Systems Inc CSCO.O:BUZZ - Reaches 25-year peak after lifting FY26 forecast; brokerages raise PT nL6N3WP0V3

** Hecla Mining Co HL.N:

** Coeur Mining Inc CDE.N:

** Endeavour Silver Corp EVX.N:

** Silvercorp Metals Inc SVM.N:

BUZZ - Silver miners gain on US Fed rate cut optimism nL6N3WP0N1

** Mersana Therapeutics Inc MRSN.O:BUZZ - Soars on Day One's $285 mln buyout deal nL6N3WP0VD

** Sealed Air Corp SEE.N:BUZZ - Soars on reports of Clayton Dubilier & Rice take-private talks nL6N3WP0YP

** Circle Internet Group Inc CRCL.N:BUZZ - Rises after JPM upgrades to 'overweight' nL4N3WM0X2

** Xunlei Ltd XNET.O:BUZZ - Jumps on Q3 profit nL4N3WP0RW

** SharpLink Gaming Inc SBET.O:BUZZ - Surges after $1.5 bln share repurchase program nL4N3WP0SU

** Claritev Corp CTEV.N:BUZZ - Slides as top holder reduces stake in healthcare tech firm nL6N3WP0PP

** Albemarle Corp ALB.N:BUZZ - Mizuho raises price target on Albemarle; shares rise nL6N3WP0QM

** Mangoceuticals Inc MGRX.O:BUZZ - Jumps after partnering with Lilly, Novo Nordisk to sell weight-loss drugs nL6N3WP0QN

** BioNTech SE BNTX.O:BUZZ - Falls after report Pfizer to sell stake in co nL6N3WP0QF

** Canadian Solar Inc CSIQ.O:BUZZ - Jumps after third-quarter revenue beat nL6N3WP0PA

** Centuri Holdings Inc CTRI.N:BUZZ - Falls after $235 mln equity raise as Icahn pitches in nL6N3WP0RB

** DoorDash Inc DASH.O:BUZZ - Up after Wedbush upgrades stock to 'outperform' nL6N3WP0RK

** Dillard's Inc DDS.N:BUZZ - Jumps after Q3 sales beat estimates nL6N3WP0RD

** Paysafe Ltd PSFE.N:BUZZ - Plummets on weaker FY25 forecast nL4N3WP11U

** Stratasys Ltd SSYS.O:BUZZ - Rise after Q3 results beat nL4N3WP0YH

** Tharimmune Inc THAR.O:BUZZ - Rises after US FDA backs opioid overdose prevention drug plan nL4N3WP0ZB

** Baytex Energy Corp BTE.N:BUZZ - BMO upgrades Baytex to outperform on Clearwater strength, lower costs nL6N3WP0SL

** Hecla Mining Co HL.N:BUZZ - Scotiabank sees Hecla Mining as safer bet; resumes coverage with 'sector perform' nL6N3WP0RR

** Firefly Aerospace Inc FLY.O:BUZZ - Surges after Q3 beat, Deutsche Bank upgrade nL6N3WP0Y1

** Ardent Health Inc ARDT.N:BUZZ - Falls after surprise quarterly loss nL4N3WP11B

** Bitdeer Technologies Inc BTDR.O:BUZZ - Plunges after direct stock, convertible bonds sale nL6N3WP0QY

** Seagate Technology Holdings PLC STX.O:

** Western Digital Corp WDC.O:

** Sandisk Corp SNDK.O:BUZZ - Memory chip stocks fall after Kioxia reports profit and sales dip nL6N3WP0QJ

** Novo Nordisk A/S NVO.N:BUZZ - Falls after Metsera shareholders vote for Pfizer's offer nL4N3WP13N

** Salarius Pharmaceuticals Inc SLRX.O:BUZZ - Jumps after completing merger with Decoy Therapeutics nL4N3WP13P

** Spectrum Brands Holdings Inc SPB.N:BUZZ - Up after Q4 profit beats estimates nL6N3WP0UC

** MarineMax Inc HZO.N:BUZZ - See-saws after boat retailer forecasts annual profit below estimates nL6N3WP0UG

** Sally Beauty Holdings Inc SBH.N:BUZZ - Rises after upbeat quarterly results nL6N3WP0W1

** Immuneering Corp IMRX.O:BUZZ - Rises after smaller-than-expected Q3 loss nL4N3WP19G

** Ionis Pharmaceuticals Inc IONS.O:BUZZ - Dips after $700 mln convertible bonds sale nL6N3WP0X6

** Kura Oncology Inc KURA.O:BUZZ - Rises after US FDA approves its blood cancer therapy nL4N3WP1AC

** Chevron Corp CVX.N:

** SLB NV SLB.N:

** Halliburton Co HAL.N:BUZZ - Oil companies climb on looming Russian export sanctions nL6N3WP0XL

** Ondas Holdings Inc ONDS.O:BUZZ - Jumps after lifting annual revenue forecast nL6N3WP0V6

** Webtoon Entertainment Inc WBTN.O:BUZZ - Plunges as brokerages cut target price after results nL6N3WP0XC

** Broadridge Financial Solutions Inc BR.N:BUZZ - UBS cuts price target on Broadridge Financial; maintains 'neutral' nL6N3WP0YL

** Shoe Carnival Inc SCVL.O:BUZZ - Up after preliminary third-quarter results beat nL6N3WP0Y8

** Broadwind Inc BWEN.O:BUZZ - Up after raising annual revenue forecast nL6N3WP0VM

** Verizon Communications Inc VZ.N:BUZZ - Rises; co to cut about 15,000 jobs, source says nL4N3WP1DY

** APA Corp APA.O:BUZZ - Gains on report Repsol considering upstream merger nL4N3WP1GO

** Annexon Inc ANNX.O:BUZZ - Slips after $75 million capital raise nL6N3WP0OQ

** Applied Materials Inc AMAT.O:BUZZ - Down with broader mkt; results due after the bell nL6N3WP10T

** Sweetgreen Inc SG.N:BUZZ - Rallies 10% after CEO buys nearly $1 mln worth of stock nL6N3WP129

(Compiled by Rajarshi Roy and Varun Sahay in Bengaluru)

((Rajarshi.Roy@thomsonreuters.com))