Eledon Pharmaceuticals Inc. has announced preliminary results from an ongoing investigator-initiated clinical trial evaluating tegoprubart, an investigational anti-CD40 Ligand (anti-CD40L) antibody, as the core immunosuppressant in islet transplantation for individuals with type 1 diabetes. The trial, conducted at the University of Chicago Medicine's Transplant Institute, is assessing a tacrolimus-free immunosuppression regimen to prevent islet transplant rejection. Preliminary data from the first six patients were presented at the Rachmiel Levine-Arthur Riggs Diabetes Research Symposium, held November 14-17, 2025, at City of Hope in Los Angeles, California. All six subjects in the preliminary cohort achieved insulin independence. The study is funded by Breakthrough T1D, which has also committed to support further research on tegoprubart in this context.