Merck Unveils Promising Early Data for MK-1045 and Bomedemstat in Hematologic Cancers at ASH 2025

Reuters

11/24

Merck Unveils Promising Early Data for MK-1045 and Bomedemstat in Hematologic Cancers at ASH 2025

Merck & Co. Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology $(ASH)$ Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Merck & Co. Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251124225525) on November 24, 2025, and is solely responsible for the information contained therein.

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Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology <a href=\"https://laohu8.com/S/ASH\">$(ASH)$</a> Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Merck &amp; Co. Inc. published the original content used to generate this news brief via Business Wire (Ref. ID: 20251124225525) on November 24, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU1941712348.USD","symbol_name":"ALLIANZ PET AND ANIMAL WELLBEING \"AT\" (USD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251124:nNDL3C1CQr:1","article_id":"2585469125","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2585469125","pubTimestamp":1763984722,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Merck & Co. 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VL \"A\" (USD) ACC","LU1989772923.USD":"CPR Invest - Climate Action A2 Acc USD-H"},"translate_title":"默克在ASH 2025上公布了MK-1045和Bomedemstat治疗血液癌症的有希望的早期数据","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"MRK":0.9},"content_text":"Merck Unveils Promising Early Data for MK-1045 and Bomedemstat in Hematologic Cancers at ASH 2025\n    \n\n        Merck & Co. Inc. announced that new data from its hematology pipeline will be presented at the American Society of Hematology $(ASH)$ Annual Meeting and Exposition in December 2025. The company will share results from multiple investigational therapies, including the first clinical presentation of MK-1045, a novel CD19xCD3 T-cell engager, in adults with relapsed or refractory B-cell acute lymphoblastic leukemia. Additionally, Merck will present initial results from the Phase 2 Shorespan-004 study of bomedemstat (MK-3543), an LSD1 inhibitor, in patients with polycythemia vera who are resistant or intolerant to cytoreductive therapy. Updated data on nemtabrutinib (MK-1026), a non-covalent BTK inhibitor, and zilovertamab vedotin (MK-2140), an antibody-drug conjugate targeting ROR1, are also scheduled for presentation. The results have not yet been presented and will be disclosed at the ASH 2025 meeting.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Merck & Co. Inc. published the original content used to generate this news brief via Business Wire (Ref. 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