Day One Biopharmaceuticals Reports Three-Year Data Showing Durable Responses for OJEMDA in Pediatric Low-Grade Glioma

Reuters

2025/11/24

Day One Biopharmaceuticals Reports Three-Year Data Showing Durable Responses for OJEMDA in Pediatric Low-Grade Glioma

Day One Biopharmaceuticals Inc. has announced updated three-year follow-up data from the Phase 2 FIREFLY-1 trial evaluating OJEMDA™ (tovorafenib) in pediatric low-grade glioma (pLGG). The results were presented at the 2025 Society for Neuro-Oncology (SNO) Annual Meeting. In the study, 77% of patients who entered a treatment-free observation period after OJEMDA therapy remained off therapy for at least 12 months. The median time to next treatment exceeded 3.5 years. Among 76 evaluable patients, the overall response rate was 53%, with a median duration of response of 19.4 months and a median progression-free survival of 16.6 months. No new safety signals were identified in the updated analysis.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Day One Biopharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9590997-en) on November 24, 2025, and is solely responsible for the information contained therein.

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The results were presented at the 2025 Society for Neuro-Oncology (SNO) Annual Meeting. In the study, 77% of patients who entered a treatment-free observation period after OJEMDA therapy remained off therapy for at least 12 months. The median time to next treatment exceeded 3.5 years. Among 76 evaluable patients, the overall response rate was 53%, with a median duration of response of 19.4 months and a median progression-free survival of 16.6 months. No new safety signals were identified in the updated analysis.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Day One Biopharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9590997-en) on November 24, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU2210149790.SGD","symbol_name":"Natixis Thematics Subscription Economy R/A SGD-H","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251124:nNDL1YdBl2:1","article_id":"2585625704","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2585625704","pubTimestamp":1763989216,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Day One Biopharmaceuticals Inc. has announced updated three-year follow-up data from the Phase 2 FIREFLY-1 trial evaluating OJEMDA  in pediatric low-grade glioma . The results were presented at the 2025 Society for Neuro-Oncology  Annual Meeting. In the study, 77% of patients who entered a treatment-free observation period after OJEMDA therapy remained off therapy for at least 12 months. The median time to next treatment exceeded 3.5 years. Among 76 evaluable patients, the overall response rate was 53%, with a median duration of response of 19.4 months and a median progression-free survival of 16.6 months. No new safety signals were identified in the updated analysis.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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The results were presented at the 2025 Society for Neuro-Oncology (SNO) Annual Meeting. In the study, 77% of patients who entered a treatment-free observation period after OJEMDA therapy remained off therapy for at least 12 months. The median time to next treatment exceeded 3.5 years. Among 76 evaluable patients, the overall response rate was 53%, with a median duration of response of 19.4 months and a median progression-free survival of 16.6 months. No new safety signals were identified in the updated analysis.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Day One Biopharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. 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