Phio Pharmaceuticals Corp. has announced the completion of enrollment in its Phase 1b clinical trial of PH-762, an INTASYL siRNA compound designed to silence the PD-1 gene implicated in various forms of skin cancer. The trial is evaluating the safety and tolerability of neoadjuvant intratumoral PH-762 in patients with cutaneous squamous cell carcinoma (cSCC), melanoma, and Merkel cell carcinoma. To date, 18 patients have completed treatment across five dose-escalating cohorts. Pathology results for the highest dose cohort are expected in Q1 2026. No dose-limiting toxicities or clinically relevant treatment-emergent adverse effects have been observed so far.
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