Wall Street's main indexes were mixed in choppy trading on Wednesday, with Microsoft pulling the tech sector lower, while investors parsed a slew of economic indicators to gauge the Fed's policy outlook. .N

At 10:30 EST, the Dow Jones Industrial Average .DJI was up 0.34% at 47,633.45.The S&P 500 .SPX was down 0.00% at 6,829.10, and the Nasdaq Composite .IXIC was down 0.23% at 23,359.58.

The top three S&P 500 .PG.INX percentage gainers:

** Microchip Technology Inc MCHP.OQ, up 8.8%

** ON Semiconductor Corp ON.OQ, up 6.2%

** Vertex Pharmaceuticals Inc VRTX.OQ, up 5.4%

The top three S&P 500 .PL.INX percentage losers:

** Alexandria Real Estate Equities Inc ARE.N, down 7.1%

** Sandisk Corp SNDK.OQ, down 6.3%

** Netflix Inc NFLX.OQ, down 5.9%

The top three NYSE .PG.N percentage gainers:

** American Eagle Outfitters Inc AEO.N, up 13.9%

** Vicarious Surgical Inc RBOT.N, up 9.2%

** Genius Sports Ltd GENI.N, up 9.1%

The top three NYSE .PL.N percentage losers:

** ADC Therapeutics SA ADCT.N, down 29.5%

** Pure Storage Inc PSTG.N, down 26.0%

** United Natural Foods Inc UNFI.N, down 8.7%

The top three Nasdaq .PG.O percentage gainers:

** Capricor Therapeutics Inc CAPR.OQ, up 247.2%

** Virax Biolabs Group Ltd VRAX.OQ, up 82.5%

** Ambitions Enterprise Management Co LLC AHMA.OQ, up 41.0%

The top three Nasdaq .PL.O percentage losers:

** Scantech AI Systems Inc STAI.OQ, down 46.5%

** Paranovus Entertainment Technology Ltd PAVS.OQ, down 40.8%

** CIMG Inc IMG.OQ, down 34.1%

** Rio Tinto PLC RIO.N:** AngloGold Ashanti PLC AU.N:BUZZ - EMEA mining to embrace strategic change in 2026, says JP Morgan nL6N3X90FG

** American Eagle Outfitters Inc AEO.N:BUZZ - Shares soar on holiday cheer and raised outlook nL4N3X90L9

** Marvell Technology Inc MRVL.O:BUZZ - Soars on Celestial AI deal, strong outlook for next year nL4N3X90MH

** Microchip Technology Inc MCHP.O:BUZZ - Climbs after improved third-quarter outlook nL6N3X90L2

** ASML Holding NV ASML.O:** STMicroelectronics NV STM.N:BUZZ - EU chips stock rally on Marvell forecasts spillover, bullish analyst comments nL8N3X90J3

** Okta Inc OKTA.O:BUZZ - Slips after forecast fails to impress nL6N3X80L3

** BHP Group Ltd BHP.N:** Southern Copper Corp SCCO.N:** Freeport-McMoRan Inc FCX.N:** Hudbay Minerals Inc HBM.N: BUZZ - Copper miners gain on record high prices, supply concerns, weaker dollar nL6N3X90WG

** Equinix Inc EQIX.O:BUZZ - BMO lifts Equinix to 'outperform', expects margin gains nL4N3X90U2

** Dollar Tree Inc DLTR.O:BUZZ - Up after raising annual profit forecast nL6N3X90P2

** Macy's Inc M.N:BUZZ - Reverses course as muted holiday forecast clouds surprise quarterly profit nL6N3X90SM

** F.N.B Corp FNB.N:** Meridian Corp MRBK.O:** Community Financial System Inc CBU.NCBU.N:** City Holding Co CHCO.O:BUZZ - Piper Sandler assumes coverage of six Mid-Atlantic regional banks nL4N3X90UV

** Black Diamond Therapeutics Inc BDTX.O:BUZZ - Rises as lung cancer drug meets main goal nL4N3X90WP

** Strategy Inc MSTR.O:BUZZ - Gains on bitcoin surge; co engages with MSCI on potential index exclusion nL6N3X90O0

** Casey's General Stores Inc CASY.O:BUZZ - Stephens raises PT on Casey's General Stores nL4N3X90VA

** GitLab Inc GTLB.O:BUZZ - Falls as investors unimpressed by forecast nL4N3X90VB

** Royal Bank of Canada RY.N:BUZZ - Gains after Q4 profit beat nL6N3X90QC

** IREN Ltd IREN.O:BUZZ - Up after pricing $2 bln convertible bonds offering, direct stock deal nL6N3X90QM

** Sprinklr Inc CXM.N:BUZZ - Gains after Q3 results beat estimates nL6N3X90R0

** Bristol Myers Squibb Co BMY.N:BUZZ - Rises as Alzheimer's trial to enroll more patients nL6N3X90SO

** Oracle Corp ORCL.N:BUZZ - Rises as Wells Fargo initiates with 'overweight' rating nL6N3X90RU

** Nuvation Bio Inc NUVB.N:BUZZ - Rises on brain cancer drug data nL4N3X9106

** Thor Industries Inc THO.N:BUZZ - Rises after Q1 results beat estimates nL4N3X910E

** Pharvaris NV PHVS.O:BUZZ - Jumps as oral therapy for genetic disorder meets main goal in late-stage trial nL6N3X90SD

** Wendy's Co WEN.O:BUZZ - Drops after JPM cuts to 'neutral' on lack of defined turnaround strategy nL4N3X90Z9

** Wyndham Hotels & Resorts WH.N:BUZZ - Gets 'neutral' rating as Mizuho starts coverage nL4N3X90ZD

** Incannex Healthcare Inc IXHL.O:BUZZ - Jumps after FDA fast-tracks sleep disorder drug nL4N3X912F

** Kestra Medical Technologies Ltd KMTS.O:BUZZ - Rebounds after boosted $138 mln stock sale nL6N3X90TQ

** Alexandria Real Estate Equities Inc ARE.N:BUZZ - Slashes quarterly dividend, shares fall nL6N3X90U3

** Pure Storage Inc PSTG.N:BUZZ - Plunges after Q3 results; JP Morgan and Citi cut PT nL6N3X90TZ

** Microsoft Corp MSFT.O:BUZZ - Falls on report of lowered AI software sales quota nL4N3X9188

** Acadia Healthcare Company Inc ACHC.O:BUZZ - Plunges after cutting 2025 profit forecast nL4N3X914V

** Daktronics Inc DAKT.O:BUZZ - Names Ramesh Jayaraman President and CEO, shares fall nL4N3X916X

** Nextpower Inc NXT.O:BUZZ - Expands US operations with new hub and manufacturing boost; shares dip nL4N3X90YT

** Capricor Therapeutics Inc CAPR.O:BUZZ - Jumps to 8-year high as cell therapy slows muscle-wasting disease nL4N3X917S

** Exxon Mobil Corp XOM.N:** Chevron Corp CVX.N:** APA Corp APA.O:** Targa Resources Corp TRGP.N:BUZZ - Energy firms rise as Moscow peace talks fail to reach breakthrough nL4N3X90S3

** EQT Corp EQT.N:** NextDecade Corp NEXT.O:** New Fortress Energy Inc NFE.O:** CNX Resources Corp CNX.N:BUZZ - Energy firms rise as Moscow peace talks fail to reach breakthrough nL4N3X90S3

(Compiled by Rajarshi Roy and Pooja Menon in Bengaluru)

((Rajarshi.Roy@thomsonreuters.com))