Wall Street's main indexes traded lower on Monday as investors stood on the sidelines, sifting through fresh economic data and bracing for a closely watched speech from Federal Reserve Chair Jerome Powell that could hint at this month's policy decision. .N

At 10:30 EST, the Dow Jones Industrial Average .DJI was down 0.72% at 47,372.57. The S&P 500 .SPX was down 0.56% at 6,810.94, and the Nasdaq Composite .IXIC was down 0.65% at 23,213.22.

The top three S&P 500 .PG.INX percentage gainers:

** Old Dominion Freight Line Inc ODFL.OQ, up 4.2%

** Synopsys Inc SNPS.OQ, up 3.7%

** Diamondback Energy Inc FANG.OQ, up 3.3%

The top three S&P 500 .PL.INX percentage losers:

** Moderna Inc MRNA.OQ, down 6.4%

** Robinhood Markets Inc HOOD.OQ, down 6.1%

** Coinbase Global Inc COIN.OQ, down 5.8%

The top NYSE .PG.N percentage gainer:

** Infinity Natural Resources Inc INR.N, up 2.4%

The top three Nasdaq .PG.O percentage gainers:

** Ambitions Enterprise Management Co LLC AHMA.OQ, up 217.7%

** Q32 Bio Inc QTTB.OQ, up 148.9%

** Fly-E Group Inc FLYE.OQ, up 102.7%

The top three Nasdaq .PL.O percentage losers:

** Paranovus Entertainment Technology Ltd PAVS.OQ, down 88.0%

** Columbus Circle Capital I Corp BRR.OQ, down 42.0%

** SMX (Security Matters) PLC SMX.OQ, down 29.5%

** Coupang Inc CPNG.N:BUZZ - Falls after South Korea's worst data breach in over a decade nL4N3X70NL

** Coinbase Global Inc COIN.O:** Bitfarms Ltd BITF.O:** Riot Platforms Inc RIOT.O:** MARA Holdings Inc MARA.O:BUZZ - Crypto-linked stocks dip after bitcoin and ethereum fall nL4N3X70O3

** Moderna Inc MRNA.O:** Novavax Inc NVAX.O:BUZZ - Vaccine makers fall after US FDA memo links child deaths to COVID shots nL4N3X70PG

** Newmont Corp NEM.N:** Gold Fields Ltd GFI.N:** Harmony Gold Mining Co Ltd HMY.N:** Sibanye Stillwater Ltd SBSW.N: BUZZ - Gold miners up as bullion hits six-week high on rate cut optimism nL4N3X70Q3

** Hecla Mining Co HL.N:** Coeur Mining Inc CDE.N:** Silvercorp Metals Inc SVM.N:BUZZ - Silver miners climb as metal prices hit record high nL6N3X70JV

** Zscaler Inc ZS.O:BUZZ - Falls after Bernstein downgrades to 'market perform' nL6N3X70KZ

**Idacorp Inc IDA.N:BUZZ - Jefferies cuts Idacorp's PT on wildfire risk nL4N3X70R8

** Kodiak Gas Services Inc KGS.N:BUZZ - Slips as EQT exits in $338 mln stock sale nL6N3X70QL

** Leggett & Platt Inc LEG.N:BUZZ - Jumps after Somnigroup's acquisition proposal nL4N3X70US

** Barrick Mining Corp B.N:BUZZ - Gains on IPO plan for North American gold assets nL6N3X70QV

** Tesla Inc TSLA.O:BUZZ - Slips as November registrations slump in key European markets nL4N3X70X2

** Clean Energy Fuels Corp CLNE.O:BUZZ - Gains as Texas RNG facility begins operation nL6N3X70LM

** Endeavour Silver Corp EXK.N:BUZZ - Dips after unveiling planned $300 mln convertible bond offering nL6N3X70MU

** Altimmune Inc ALT.O:BUZZ - Falls as CEO Vipin Garg to step down nL4N3X70YZ

** Canadian Solar Inc CSIQ.O:BUZZ - Surges on US expansion and manufacturing reshoring strategy nL6N3X70N6

** Exelon Corp EXC.O:BUZZ - Drops after announcing $900 mln convertible debt offering nL6N3X70NX

** Old Dominion Freight Line Inc ODFL.O:BUZZ - BMO lifts Old Dominion Freight Line to 'outperform', slashes PT nL4N3X712D

** Belite Bio Inc BLTE.O:BUZZ - Surges after eye drug meets main goal in late-stage study nL6N3X70NR

** Accenture PLC ACN.N:BUZZ - Rises on OpenAI tie-up nL4N3X712O

** Strategy Inc MSTR.O:BUZZ - Slips as bitcoin selloff prompts sharp forecast cut nL4N3X7132

** Daré Bioscience Inc DARE.O:BUZZ - Rises as Bayer exits Ovaprene partnership deal nL4N3X7128

** Synopsys Inc SNPS.O:BUZZ - Gains on Nvidia's $2 billion investment nL6N3X70QO

** Ideaya Biosciences Inc IDYA.O:BUZZ - Rises as FDA clears trial for experimental cancer drug nL4N3X714B

** USA Compression Partners LP USAC.N:BUZZ - Gains on plans to acquire J-W Power for $860 million nL6N3X70M6

** American Airlines Group Inc AAL.O:** United Airlines Holdings Inc UAL.O:** Southwest Airlines Co LUV.N:BUZZ - Airbus recalls A320 jets, US airlines shares fall nL4N3X710I

** FuelCell Energy Inc FCEL.O:BUZZ - Secures $25 million EXIM loan; shares down nL4N3X10P4

** Omnicom Group Inc OMC.N:BUZZ - Up as co lays off more than 4,000 employees nL4N3X71A5

** Targa Resources Corp TRGP.N:BUZZ - Gains on deal to acquire Stakeholder Midstream for $1.25 bln nL6N3X70RV

(Compiled by Rajarshi Roy and Pooja Menon in Bengaluru)

((Rajarshi.Roy@thomsonreuters.com))