Fate Therapeutics Inc. has presented updated clinical data from its ongoing Phase 1 trial evaluating FT819, an off-the-shelf iPSC-derived CAR T-cell product candidate, in patients with systemic lupus erythematosus $(SLE)$. The data, presented at the 2025 American Society of Hematology $(ASH)$ Annual Meeting & Exposition, include results from 13 enrolled patients-12 with SLE and one with systemic sclerosis. The updated findings show sustained clinical responses, durable B-cell depletion, and a favorable safety profile without the need for intensive-conditioning chemotherapy. Fate Therapeutics also announced preclinical advances in its next-generation off-the-shelf CAR T-cell programs, FT836 and FT839, targeting hematologic malignancies and autoimmune diseases. The company is preparing for a registrational study of FT819 in 2026 and is in discussions with the U.S. FDA under the Regenerative Medicine Advanced Therapy (RMAT) designation.