Fulcrum Shares Soar on Sickle-Cell Treatment Trial Results

Dow Jones

2025/12/08

By Nicholas G. Miller

Shares of Fulcrum Therapeutics soared after the company released positive initial results from a trial of its pociredir drug to treat sickle-cell disease.

The stock rose 47% to $13.06 in premarket trading. Shares were up 89% this year as of Friday.

The clinical-stage biopharmaceutical company late Saturday said initial results from the 20-milligram dose cohort of the trial showed robust and clinically meaningful increases in fetal hemoglobin.

Fulcrum, based in Cambridge, Mass., also said the drug continued showing a favorable safety profile with no treatment-related severe adverse events reported.

Write to Nicholas G. Miller at nicholas.miller@wsj.com.

(END) Dow Jones Newswires

December 08, 2025 06:42 ET (11:42 GMT)

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Miller \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  Shares of <a href=\"https://laohu8.com/S/FULC\">Fulcrum Therapeutics</a> soared after the company released positive initial results from a trial of its pociredir drug to treat sickle-cell disease. \n</p>\n<p>\n  The stock rose 47% to $13.06 in premarket trading. Shares were up 89% this year as of Friday. \n</p>\n<p>\n  The clinical-stage biopharmaceutical company late Saturday said initial results from the 20-milligram dose cohort of the trial showed robust and clinically meaningful increases in fetal hemoglobin. \n</p>\n<p>\n  Fulcrum, based in Cambridge, Mass., also said the drug continued showing a favorable safety profile with no treatment-related severe adverse events reported. \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  Write to Nicholas G. Miller at nicholas.miller@wsj.com. \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  (END) Dow Jones Newswires\n</p>\n<p>\n  December 08, 2025 06:42 ET (11:42 GMT)\n</p>\n<p>\n  Copyright (c) 2025 Dow Jones &amp; Company, Inc.\n</p>\n</font>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"FULC","symbol_name":"Fulcrum Therapeutics","start_time":0,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","article_id":"2589808337","we_media_id":"106","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2589808337","pubTimestamp":1765194120,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Dow Jones","introduction":"Dow Jones publishes the world’s most trusted business news and financial information in a variety of media.","home_visible":0,"id":"106","head_image":"https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99"},"summary":"Shares of Fulcrum Therapeutics soared after the company released positive initial results from a trial of its pociredir drug to treat sickle-cell disease.The stock rose 47% to $13.06 in premarket trading. Shares were up 89% this year as of Friday.The clinical-stage biopharmaceutical company late Saturday said initial results from the 20-milligram dose cohort of the trial showed robust and clinically meaningful increases in fetal hemoglobin.Fulcrum, based in Cambridge, Mass., also said the drug continued showing a favorable safety profile with no treatment-related severe adverse events reported.","collect":0,"end_time":0,"defaultTopTitle":"","property":[],"viewcount":null,"language":"en","relate_stocks":{"FULC":"Fulcrum Therapeutics","BK4007":"制药"},"translate_title":"Fulcrum股价因镰状细胞治疗试验结果而飙升","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"FULC":0.9},"content_text":"By Nicholas G. Miller \n\n\n \n\n\n  Shares of Fulcrum Therapeutics soared after the company released positive initial results from a trial of its pociredir drug to treat sickle-cell disease. \n\n\n  The stock rose 47% to $13.06 in premarket trading. Shares were up 89% this year as of Friday. \n\n\n  The clinical-stage biopharmaceutical company late Saturday said initial results from the 20-milligram dose cohort of the trial showed robust and clinically meaningful increases in fetal hemoglobin. \n\n\n  Fulcrum, based in Cambridge, Mass., also said the drug continued showing a favorable safety profile with no treatment-related severe adverse events reported. \n\n\n \n\n\n  Write to Nicholas G. Miller at nicholas.miller@wsj.com. \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 08, 2025 06:42 ET (11:42 GMT)\n\n\n  Copyright (c) 2025 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"2","news_tag":"dataReport","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":true,"code":"91000000","status":"200"}}}