TransThera Sciences (Nanjing) Inc. has announced the publication of clinical results from a US-based Phase 2 trial evaluating tinengotinib (TT-00420) in patients with cholangiocarcinoma $(CCA)$. The findings have been published in The Lancet Gastroenterology and Hepatology. The multicenter, open-label Phase 2 trial enrolled patients with FGFR2 fusion-positive CCA who had demonstrated resistance to prior FGFR inhibitor therapy, as well as patients with other FGFR alterations and FGFR wild-type tumors. Tinengotinib demonstrated clinical activity, including durable responses and meaningful clinical benefit, in patients with FGFR2 fusion-positive CCA with acquired resistance to FGFR inhibitors, as well as in other FGFR-altered subtypes. The results support further clinical investigation in a Phase 3 registration study.