Prime Medicine Reports Positive Phase 1/2 Results for PM359 in Chronic Granulomatous Disease

Reuters

2025/12/07

<a href="https://laohu8.com/S/PRME">Prime Medicine</a> Reports Positive Phase 1/2 Results for PM359 in Chronic Granulomatous Disease

Prime Medicine Inc. announced the publication of Phase 1/2 clinical data for PM359, its investigational autologous hematopoietic stem cell product for p47phox chronic granulomatous disease (CGD), in the New England Journal of Medicine. The initial results from two patients in the trial showed rapid neutrophil and platelet engraftment, durable restoration of NADPH oxidase activity, and early clinical benefit without any safety concerns related to PM359. Both patients remained free of new CGD-related complications following treatment. The data will also be presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting, scheduled for December 6-9, 2025, in Orlando, Florida.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Prime Medicine Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9598091-en) on December 07, 2025, and is solely responsible for the information contained therein.

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The initial results from two patients in the trial showed rapid neutrophil and platelet engraftment, durable restoration of NADPH oxidase activity, and early clinical benefit without any safety concerns related to PM359. Both patients remained free of new CGD-related complications following treatment. The data will also be presented at the 67th American Society of Hematology <a href=\"https://laohu8.com/S/ASH\">$(ASH)$</a> Annual Meeting, scheduled for December 6-9, 2025, in Orlando, Florida.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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Prime Medicine Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. 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The initial results from two patients in the trial showed rapid neutrophil and platelet engraftment, durable restoration of NADPH oxidase activity, and early clinical benefit without any safety concerns related to PM359. Both patients remained free of new CGD-related complications following treatment. The data will also be presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting, scheduled for December 6-9, 2025, in Orlando, Florida.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Prime Medicine Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. 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