Natera Inc., a global leader in cell-free DNA and precision medicine, has announced a collaboration with MEDSIR, a prominent oncology research organization, for the MiRaDoR phase II clinical trial in hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer. The study will use Natera's Signatera Genome technology to evaluate the effectiveness of different therapeutic approaches in early-stage HR+/HER2- breast cancer patients. The trial aims to assess the ability of various treatment combinations to reduce circulating-tumor DNA as a marker of treatment response, potentially setting a new standard for precision oncology clinical trials. The collaboration is supported by funding from F. Hoffman-La Roche Ltd. and is currently enrolling patients across several sites, with further expansions planned in Europe.