Castle Biosciences Inc. announced new data from the largest prospective, multicenter study to date comparing next-generation sequencing $(NGS)$-based gene mutation analysis with the combination of DecisionDx-UM and PRAME gene expression for predicting outcomes in patients with uveal melanoma (UM). The study, titled "Early Genetic Evolution of Driver Mutations in Uveal Melanoma," was conducted by the Collaborative Ocular Oncology Group (COOG) and has been published in Nature Communications. Results showed that the combination of DecisionDx-UM and PRAME outperformed gene mutation analysis in predicting metastasis-free survival and overall survival in UM patients. The study authors attribute the improved performance to the ability of DecisionDx-UM to measure gene activity from both tumor and surrounding immune cells, providing a comprehensive assessment of the tumor microenvironment.