** Vaccine stocks conclude 2025 with losses, with Pfizer PFE.N, Moderna MRNA.O, Novavax NVAX.O and BioNTech 22UAy.DE, BNTX.O all in red

** U.S. vaccines have been under pressure since vaccine-skeptic Robert F. Kennedy Jr. became health secretary and has worked to reduce the country's reliance on the interventions

** Shares of Pfizer have fallen 5.8% this year; shares of the company have dropped more than 50% since early 2023 as demand for COVID-19 vaccines and treatments waned

** Shares of Moderna are down 26.9% this year, on track for a fourth straight year of losses

** Kennedy, a longtime vaccine skeptic, has made far-reaching changes to the U.S. vaccine policy, which include dropping a long-standing recommendation for the hepatitis B birth dose, cutting funding for mRNA vaccines and, contrary to established science, linking vaccines to autism

** Shares of Novavax have fallen 16.4% this year after rising 67.5% in 2024; the company pushed back its profitability target by a year to 2028

** U.S. listed shares of BioNTech are down 16.4% this year after rising about 8% in 2024

(Reporting by Sneha S K)

((Sneha.SK@thomsonreuters.com;))