Replimune Group Inc. presented new data highlighting progress in its oncolytic immunotherapy platform, particularly in the treatment of melanoma. The company reported that approximately 1,000 patients have been treated across its RPx platform, with around 1,200 deep injections administered. The presentation included results from the IGNYTE study, which evaluated RP1 in combination with nivolumab in patients with anti-PD-1-failed melanoma. In a cohort of 140 patients, the overall response rate $(ORR)$ was 33.6%, with a median duration of response of 24.8 months. Subgroup analyses showed consistent response rates, including a 26.2% ORR for patients previously treated with both anti-PD-1 and anti-CTLA-4 therapies, and a 25.0% ORR for those with advanced stage IVb-IVd disease. The company noted that its commercial team is prepared for a potential product launch, with logistics and operational strategies in place. You can access the full presentation through the link below.

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