Kala Bio (KALA) shares were up 61% in Wednesday's premarket activity, after the biopharmaceutical company said its Researgency.ai platform is now live, with the first artificial intelligence agent expected to be deployed in about 14 days.

Domo (DOMO) stock was 45% higher after the company reported overnight a swing to fiscal Q4 non-GAAP earnings and higher revenue.

Auna (AUNA) shares were up 22% after the company reported late Tuesday higher Q4 revenue.

Oracle (ORCL) stock was up 10%, a day after the company reported higher fiscal Q3 adjusted earnings and revenue, and set higher-than-expected fiscal Q4 adjusted EPS outlook.