European equities traded in the US as American depositary receipts were heading lower late Wednesday morning, declining 0.54% to 1,835.78 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by medical device maker EDAP TMS (EDAP) and biopharmaceutical firm Grifols (GRFS), which advanced 3% and 2.6%, respectively. They were followed by software company SAP (SAP) and biopharmaceutical company argenx (ARGX), which increased 2.5% each.

The decliners from continental Europe were led by furniture maker Natuzzi (NTZ) and telecommunications company Nokia (NOK), which dropped 4.2% and 1.6%, respectively. They were followed by telecommunications company Ericsson (ERIC) and petroleum refiner Equinor (EQNR), which lost 1.5% and 1.2%, respectively.

The gainers from the UK were led by biopharmaceutical company Biodexa Pharmaceuticals (BDRX) and software company Endava (DAVA), which rose 3.2% each. They were followed by biopharmaceutical companies Amarin (AMRN) and NuCana (NCNA), which were up 3% and 2.3% respectively.

The decliners from the UK and Ireland were led by biotech firm Trinity Biotech (TRIB) and biopharmaceutical company Mereo BioPharma Group (MREO), which fell 2.9% and 2.6% respectively. They were followed by pharmaceutical company AstraZeneca (AZN) and utilities company National Grid (NGG), which were down 1.3% and 1.2% respectively.