Psyence Biomedical (PBM) shares were down 15% in Wednesday premarket activity, extending Tuesday's loss.

Target Hospitality (TH) stock was 9.3% lower, a day after the company said selling shareholders priced a secondary offering of 7 million shares at $14 per share, for about $98 million in gross proceeds.

Calix (CALX) stock was 9% lower, after Northland Securities downgraded the company to market perform from outperform and lowered its price target to $52 from $75.

TE Connectivity (TEL) shares were down 5.5% after the company reported lower-than-expected fiscal Q2 net sales.