European equities traded in the US as American depositary receipts were lower late Wednesday morning, declining 0.45% to 1,779.46 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by telecommunications firm Nokia (NOK) and medical device maker EDAP (EDAP), which rose 6.1% and 3.8% respectively. They were followed by petroleum refiner Equinor (EQNR) and Banco Santander (SAN), which were up 2.7% and 1% respectively.

The decliners from continental Europe were led by biopharmaceutical company Cellectis (CLLS) and healthcare tech firm Royal Philips (PHG), which fell 6.1% and 5.6% respectively. They were followed by internet browser company Opera (OPRA) and semiconductor company Sequans Communications (SQNS), which lost 3.2% and 3.1% respectively.

The gainers from the UK were led by communications company WPP (WPP) and software firm Endava (DAVA), which advanced 2.7% and 1.2% respectively. They were followed by oil and gas company Shell (SHEL) and educational publisher Pearson (PSO), which increased 1% and 0.7% respectively.

The decliners from the UK and Ireland were led by Akari Therapeutics (AKTX) and pharmaceutical company GSK (GSK), which fell 8% and 7% respectively. They were followed by Silence Therapeutics (SLN) and Mereo BioPharma Group (MREO), which were down 5.8% and 5.5% respectively.