Biogen, Denali Say Parkinson's Drug Didn't Meet Trial Endpoints -- Update

Dow Jones

05/22

By Katherine Hamilton

A drug being developed by Biogen and Denali Therapeutics to treat Parkinson's didn't slow down progression of the disease in a recent trial.

The drug companies said Thursday they are discontinuing further development of BIIB122 in idiopathic Parkinson's disease based on the results.

Denali shares retreated 7% to $18, while Biogen's stock declined 1% to $187.49.

BIIB122, which is in a Phase 2b trial to treat early-stage Parkinson's, failed to meet its primary or secondary endpoints in the study.

The trial involved 648 participants from ages 30 to 80 with early-stage Parkinson's. They received treatment for at least 48 weeks and up to 144 weeks.

BIIB122 was an investigational small molecule inhibitor of LRRK2, a gene that has been linked to Parkinson's.

Denali will continue to conduct a Phase 2a study evaluating the small molecular inhibitor in carriers of a pathogenic LRRK2 variant.

Write to Katherine Hamilton at katherine.hamilton@wsj.com

(END) Dow Jones Newswires

May 21, 2026 19:00 ET (23:00 GMT)

Copyright (c) 2026 Dow Jones & Company, Inc.

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They received treatment for at least 48 weeks and up to 144 weeks. \n\n\n  BIIB122 was an investigational small molecule inhibitor of LRRK2, a gene that has been linked to Parkinson's. \n\n\n  Denali will continue to conduct a Phase 2a study evaluating the small molecular inhibitor in carriers of a pathogenic LRRK2 variant. \n\n\n \n\n\n  Write to Katherine Hamilton at katherine.hamilton@wsj.com \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  May 21, 2026 19:00 ET (23:00 GMT)\n\n\n  Copyright (c) 2026 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-1","news_tag":"dataReport","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":0,"need_auth":true,"need_login_tip":false,"code":"91000000","status":"200"}}}